- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
Melatonin Nasal Spray
Pre-mixed intranasal melatonin research solution in metered pump bottles
- FormPre-mixed aqueous solution in a bottle fitted with a metered spray pump
- Mol. weight232.28 g/mol
- Research areasCircadian biology, pineal signalling, sleep-model pharmacology, intranasal and route-comparison studies
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Melatonin nasal spray is a pre-mixed aqueous solution of melatonin — N-acetyl-5-methoxytryptamine, the indoleamine secreted by the pineal gland — presented in a bottle fitted with a metered spray pump. It is supplied in 15 mL and 30 mL fills, both ready to dispense with no weighing, reconstitution or solvent handling at the bench.
The format exists because route of administration is itself a research question for melatonin. The molecule is small and lipophilic but is subject to extensive first-pass hepatic metabolism when swallowed, so oral bioavailability is both low and highly variable between subjects. Nasal mucosa is thin, richly vascularised and drains without passing through the liver first, which makes intranasal delivery a long-standing comparator in pharmacokinetic work — including studies asking whether the olfactory region offers any route to the central nervous system that bypasses systemic circulation.
Specifications
Identity
- CAS number
- 73-31-4
- Molecular formula
- C13H16N2O2
- Molecular weight
- 232.28 g/mol
Supply & purity
- Form
- Pre-mixed aqueous solution in a bottle fitted with a metered spray pump
- Available sizes
- 15 mL and 30 mL fill volumes
Additional detail
- Concentration
- Printed on the bottle label and restated on the lot-matched COA
- Metered pump
- Delivers a fixed volume per actuation, typically around 0.1 mL for nasal pumps of this size
- Active compound
- Melatonin (N-acetyl-5-methoxytryptamine)
- Compound class
- Indoleamine neurohormone (small molecule, not a peptide)
- Receptor targets
- MT1 and MT2 G-protein-coupled melatonin receptors
- Reconstitution
- None required — supplied pre-mixed and ready to dispense
- Research areas
- Circadian biology, pineal signalling, sleep-model pharmacology, intranasal and route-comparison studies
- Storage
- 2–8 °C, upright and protected from light; do not freeze the filled bottle
- Stability note
- Melatonin in solution photodegrades — keep in the original light-protected bottle
Questions about Melatonin Nasal Spray
How is this different from the melatonin vial?
The molecule is identical. The vial is lyophilized powder that has to be weighed or reconstituted, while this is a pre-mixed aqueous solution in a metered pump bottle, ready to dispense. The spray suits route-comparison and delivery-characterisation work; the vial suits studies needing a concentration you set yourself.
What concentration is the solution?
The concentration for your bottle is printed on the label and restated on the lot-matched certificate of analysis. Record that documented value with your data rather than assuming a standard strength, since fills can differ between production lots.
How much does one actuation deliver?
Nasal pumps of this size typically dispense a fixed volume of roughly 0.1 mL per actuation, but the value that matters is the one you verify. Prime the pump, then determine actuation volume gravimetrically over several sprays before using it as a quantitative parameter.
Why study melatonin intranasally at all?
Swallowed melatonin is heavily metabolised on first pass through the liver, so systemic exposure is low and variable. The nasal route bypasses that, which makes it a useful pharmacokinetic comparator, and a separate research question concerns possible nose-to-brain transport routes.
How should the spray be stored?
Refrigerate at 2–8 °C, keep the bottle upright and protected from light, and do not freeze it. Melatonin degrades under light in aqueous solution, so the original light-protected bottle should stay the storage container throughout the study.
Is this a sleep aid I can use?
No. Despite the familiar molecule, this is a research article supplied for laboratory investigation only. It is not a supplement, food or medicine, it is not approved for human or veterinary administration, and it must not be resold for consumption.
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