- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
NAD+ Nasal Spray
Pre-mixed intranasal NAD+ research solution in a 15 mL metered pump bottle
- FormPre-mixed aqueous solution, 15 mL bottle with metered spray pump
- Mol. weight663.43 g/mol
- Research areasMitochondrial energy metabolism, sirtuin and PARP biology, NAD+ salvage pathway, intranasal delivery models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
NAD+ Nasal Spray supplies nicotinamide adenine dinucleotide as a ready-to-use aqueous research solution in a 15 mL bottle fitted with a metered pump. NAD+ is a pyridine dinucleotide coenzyme (CAS 53-84-9) that shuttles electrons in glycolysis, the tricarboxylic acid cycle and oxidative phosphorylation, and that also serves as the consumed substrate of the sirtuin deacetylases, PARP DNA-repair enzymes and CD38 ectoenzymes. Because those consuming enzymes turn NAD+ over continuously, intracellular pools are dynamic, and NAD+ availability has become one of the more heavily studied variables in mitochondrial and cellular-aging research.
This format exists so that laboratories comparing delivery routes do not have to weigh, reconstitute and sterile-filter powder before every session. The spray arrives pre-formulated at a known concentration — 300 mg or 600 mg of NAD+ per 15 mL, i.e. 20 mg/mL or 40 mg/mL — which makes it convenient for intranasal and mucosal-absorption models where investigators want a reproducible volume per actuation rather than a volumetric dilution series.
Intranasal administration is studied because the nasal epithelium is thin, richly vascularised and adjacent to olfactory and trigeminal pathways that have been examined as routes bypassing first-pass hepatic metabolism. Whether any given molecule actually crosses in meaningful quantity is compound-specific and still under investigation, and NAD+ is a large, highly polar, negatively charged dinucleotide — which is precisely why route-comparison work on it continues. Supplied for laboratory research use only.
Specifications
Identity
- CAS number
- 53-84-9
- Molecular formula
- C21H27N7O14P2
- Molecular weight
- 663.43 g/mol
Supply & purity
- Form
- Pre-mixed aqueous solution, 15 mL bottle with metered spray pump
- Available sizes
- 15 mL (300 mg total), 15 mL (600 mg total)
Additional detail
- Concentration
- 20 mg/mL (300 mg fill) or 40 mg/mL (600 mg fill)
- Purity (raw material)
- ≥99% by HPLC; lot-matched COA available
- Active compound
- NAD+ (nicotinamide adenine dinucleotide), free acid
- Compound class
- Pyridine dinucleotide coenzyme (small molecule, not a peptide)
- Research areas
- Mitochondrial energy metabolism, sirtuin and PARP biology, NAD+ salvage pathway, intranasal delivery models
- Reconstitution
- None required — supplied pre-mixed and ready to dispense
- Storage
- 2–8 °C, upright, protected from light; do not freeze the filled bottle
- Stability note
- NAD+ in aqueous solution degrades faster at warm or alkaline conditions — keep cold and use within the study window
Questions about NAD+ Nasal Spray
How much NAD+ does each bottle contain?
Two fills are offered, both in a 15 mL bottle: 300 mg total, which works out to 20 mg/mL, and 600 mg total, which is 40 mg/mL. The concentration is printed on the label and restated on the lot-matched COA so calculations can be checked against the documented value.
Is the NAD+ third-party tested, and can I see a COA?
Yes. The NAD+ raw material is third-party tested by HPLC to ≥99% purity with identity confirmation, and a lot-matched Certificate of Analysis is available for the batch you receive. Match the lot number on the bottle to the COA before recording results.
Does it need reconstitution?
No. It ships pre-mixed as an aqueous solution, so there is no weighing, solvent addition or filtration step. That is the main reason laboratories choose the spray format when they want to remove reconstitution variability from a route-comparison experiment.
How should the bottle be stored?
Refrigerate at 2–8 °C, upright and protected from light, and do not freeze the filled bottle — freezing risks cracking and can disrupt the pump. NAD+ in solution is less stable than lyophilised powder, so cold storage and a short in-use window are important.
Is NAD+ a peptide?
No. NAD+ is a dinucleotide coenzyme built from nicotinamide mononucleotide and adenosine monophosphate, molecular formula C21H27N7O14P2. It is catalogued alongside research peptides because it appears in the same mitochondrial and longevity research programmes, not because of structural similarity.
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