- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Liraglutide
Palmitoylated 31-residue GLP-1 receptor agonist analog, research grade
- FormLyophilized powder, sealed glass vial with flip-off seal
- Mol. weight3751.20 g/mol
- Research areasGLP-1 receptor signaling, insulin secretion, appetite and gastric-emptying models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Historically it is the molecule that proved lipidation could turn a fragile incretin into a durable tool compound, and it remains a common reference in that literature. Laboratories use liraglutide as a benchmark GLP-1 receptor agonist in cyclic-AMP and beta-arrestin assays, in islet and beta-cell secretion studies, and in rodent food-intake models, particularly when the goal is to compare an older single-agonist reference against newer diacid-acylated or multi-receptor peptides.
Specifications
Identity
- CAS number
- 204656-20-2
- Molecular formula
- C172H265N43O51
- Molecular weight
- 3751.20 g/mol
- Amino acid sequence
- His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(gamma-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
- Peptide class
- Acylated GLP-1 receptor agonist analog (incretin mimetic)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial with flip-off seal
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Backbone length
- 31 amino acids, based on GLP-1(7-37)
- Research areas
- GLP-1 receptor signaling, insulin secretion, appetite and gastric-emptying models
Questions about Liraglutide
How does liraglutide differ from semaglutide?
Both are acylated GLP-1 receptor agonist analogs, but liraglutide carries a C16 palmitoyl chain and no Aib substitution, giving a shorter circulating persistence. Semaglutide adds Aib at position 2 and a C18 diacid, which markedly extends its half-life in published pharmacokinetic work.
Why is liraglutide still used in research?
It is one of the most thoroughly characterized GLP-1 agonists available, so it makes a dependable reference arm. Its self-association behavior also makes it a useful model system for biophysical studies of lipidated peptides.
What purity and documentation do you provide?
Each lot is HPLC tested to at least 99% purity with identity confirmed by mass spectrometry. A lot-matched certificate of analysis is available and corresponds to the vial number shipped, so results can be traced to the exact material used.
Does it dissolve easily?
It reconstitutes in bacteriostatic water, though the palmitoyl chain makes it slower to clear than unmodified peptides. Add solvent gently down the wall, swirl and allow time; some laboratories use a mildly alkaline buffer to aid dissolution before adjusting to assay conditions.
How should the vial be stored?
Keep the sealed lyophilized vial at −20 °C, protected from light and moisture. After reconstitution, store at 2–8 °C, protect from light and use within your documented study window. Aliquot so the stock avoids repeated freeze-thaw cycles.
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