- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Mazdutide
Oxyntomodulin-based dual GLP-1 and glucagon receptor agonist peptide
- FormLyophilized powder, sealed glass vial with flip-off seal
- Research areasEnergy expenditure, hepatic substrate handling, incretin-glucagon receptor balance
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Its interest as a research tool comes from that natural template. Where survodutide and retatrutide are engineered scaffolds, mazdutide follows the receptor balance nature already built into oxyntomodulin, which makes it useful for asking whether an oxyntomodulin-like ratio behaves differently from a designed one. Investigators use it in cyclic-AMP potency panels, hepatocyte and adipocyte assays, and rodent energy-balance work where glucagon-driven expenditure and GLP-1-driven intake reduction are measured together.
Specifications
Identity
- CAS number
- 2259884-42-1
- Peptide class
- Acylated oxyntomodulin analog; dual GLP-1 / glucagon receptor agonist
Supply & purity
- Form
- Lyophilized powder, sealed glass vial with flip-off seal
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg, 20 mg
- Solubility
- Bacteriostatic water; dilute alkaline or phosphate buffers also used
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Also cited as
- IBI362 and LY3305677 in the research literature
- Structural notes
- Proglucagon-family backbone with protease-resistant substitutions and a lipid side chain for albumin binding
- Research areas
- Energy expenditure, hepatic substrate handling, incretin-glucagon receptor balance
Questions about Mazdutide
What is mazdutide based on?
It is an analog of oxyntomodulin, a naturally occurring proglucagon-derived peptide that activates both the GLP-1 and glucagon receptors. Stabilizing substitutions and a fatty-acid side chain give it a working duration native oxyntomodulin does not have.
Is it the same compound as IBI362 or LY3305677?
Yes. Mazdutide appears under both development codes in the pharmacology literature. Searching all three names is useful when assembling references, since older papers often use only the code.
How does it compare with survodutide?
Both engage the glucagon and GLP-1 receptors, but they come from different design lineages and differ in receptor potency ratio. Laboratories often run them side by side precisely to test whether that ratio changes the metabolic phenotype observed.
What purity and documentation are supplied?
Each lot is HPLC tested to at least 99% purity with mass-spectrometric identity confirmation, and a lot-matched certificate of analysis is available. The COA is tied to the vial number shipped so data remains traceable to that material.
How should the vial be stored?
Store the sealed lyophilized vial at −20 °C, protected from light and moisture. After reconstitution, keep the solution at 2–8 °C, protect it from light and use it within your documented study window. Aliquot to avoid freeze-thaw cycling.
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