- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
P-21 Nasal Spray
Pre-mixed P-21 (P021) CNTF-mimetic spray in a metered 15 mL or 30 mL bottle
- FormPre-mixed solution in a tinted bottle with metered fine-mist spray pump
- Mol. weight1017.24 g/mol
- Research areasAdult neurogenesis, BDNF and CREB signalling, tau-pathology models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
This is the pre-mixed spray format of P-21, also written P021 — a small synthetic mimetic built from the active region of ciliary neurotrophic factor. The molecule is not a plain peptide fragment: its designers reduced the CNTF motif to a short core, capped the N-terminus with an acetyl group, amidated the C-terminus and attached an adamantane moiety, producing something markedly more lipophilic and protease-resistant than the parent sequence.
That chemistry is exactly why the spray format exists. P-21 has limited aqueous solubility, so preparing it from lyophilized powder means working with a co-solvent and checking for precipitation at the final dilution — an easy step to get wrong. Supplied as a filled bottle with a metered atomiser pump, the solubilising work is already done and verified, the concentration is fixed for the lot, and the metered pump delivers a repeatable volume per actuation, which matters when a study needs consistent aliquots across a group.
Specifications
Identity
- CAS number
- 1370554-01-0
- Molecular weight
- 1017.24 g/mol
Supply & purity
- Form
- Pre-mixed solution in a tinted bottle with metered fine-mist spray pump
- Available sizes
- 15 mL, 30 mL
Additional detail
- Concentration
- Fixed per lot — stated on the bottle label and lot certificate of analysis
- Active compound
- P-21 (P021), adamantylated CNTF-derived peptide mimetic
- Purity (raw material)
- ≥99% by HPLC with mass-spectrometric identity confirmation
- Core structure
- Ac-Asp-Gly-Gly-Leu-Ag-NH2, where Ag denotes an adamantylated glycine residue
- Parent protein
- Ciliary neurotrophic factor (CNTF)
- Vehicle
- Buffered aqueous solution with a solubilising co-solvent fraction and preservative
- Reconstitution
- None required — supplied ready to dispense
- Research areas
- Adult neurogenesis, BDNF and CREB signalling, tau-pathology models
- Storage
- 2–8 °C, upright and protected from light; do not freeze the filled bottle
Questions about P-21 Nasal Spray
Why buy the spray instead of the vial?
P-21 has limited aqueous solubility because of its adamantane group, so preparing it from powder requires a co-solvent step and precipitation checks at the working dilution. The spray arrives already formulated and verified, with a metered pump giving a repeatable dispensed volume.
Is a certificate of analysis available?
Yes. The raw material is HPLC-tested and mass-spec confirmed before formulation, and a lot-matched COA is available on request. This matters particularly for P-21, since published structural identifiers for the compound differ between suppliers and reference databases.
Does it need reconstitution?
No. The bottle ships pre-mixed and ready to dispense. Prime the pump into waste until the mist is consistent, then use as your protocol specifies. No weighing, dissolution or co-solvent preparation is required by the receiving laboratory.
How should it be stored?
Refrigerate at 2 to 8 °C, upright and away from light, and do not freeze the filled bottle — freeze-thaw risks precipitation given the compound's solubility profile. Warm to room temperature before priming, and keep the in-use window short once the seal is broken.
Can this be used intranasally by a person?
No. Despite the spray hardware, this is a laboratory research reagent for qualified personnel only. P-21 is not an approved drug, supplement or cosmetic anywhere, and the product must not be administered to humans or to animals outside an approved research protocol.
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