- Purity (raw material): ≥99% by HPLC with mass-spectrometric identity confirmation
- Lot-matched certificate of analysis
- Ships next business day, tracked
Cognitive, Mood & Sleep Peptides
P-21 Nasal Spray
Pre-mixed P-21 (P021) CNTF-mimetic spray in a metered 15 mL or 30 mL bottle
- FormPre-mixed solution in a tinted bottle with metered fine-mist spray pump
- Mol. weight1017.24 g/mol
- Research areasAdult neurogenesis, BDNF and CREB signalling, tau-pathology models
Overview
This is the pre-mixed spray format of P-21, also written P021 — a small synthetic mimetic built from the active region of ciliary neurotrophic factor. The molecule is not a plain peptide fragment: its designers reduced the CNTF motif to a short core, capped the N-terminus with an acetyl group, amidated the C-terminus and attached an adamantane moiety, producing something markedly more lipophilic and protease-resistant than the parent sequence.
That chemistry is exactly why the spray format exists. P-21 has limited aqueous solubility, so preparing it from lyophilized powder means working with a co-solvent and checking for precipitation at the final dilution — an easy step to get wrong. Supplied as a filled bottle with a metered atomiser pump, the solubilising work is already done and verified, the concentration is fixed for the lot, and the metered pump delivers a repeatable volume per actuation, which matters when a study needs consistent aliquots across a group.
Specifications
Identity
- CAS number
- 1370554-01-0
- Molecular weight
- 1017.24 g/mol
Supply & purity
- Form
- Pre-mixed solution in a tinted bottle with metered fine-mist spray pump
- Available sizes
- 15 mL, 30 mL
Additional detail
- Concentration
- Fixed per lot — stated on the bottle label and lot certificate of analysis
- Active compound
- P-21 (P021), adamantylated CNTF-derived peptide mimetic
- Purity (raw material)
- ≥99% by HPLC with mass-spectrometric identity confirmation
- Core structure
- Ac-Asp-Gly-Gly-Leu-Ag-NH2, where Ag denotes an adamantylated glycine residue
- Parent protein
- Ciliary neurotrophic factor (CNTF)
- Vehicle
- Buffered aqueous solution with a solubilising co-solvent fraction and preservative
- Reconstitution
- None required — supplied ready to dispense
- Research areas
- Adult neurogenesis, BDNF and CREB signalling, tau-pathology models
- Storage
- 2–8 °C, upright and protected from light; do not freeze the filled bottle
Units and conversions
This is a pre-mixed presentation: the strength is fixed at fill, and the only arithmetic between the label and the bench is a change of units. The peptide unit converter moves between mg, mcg, mL and µL without the decimal-point slip that costs a whole run.
Certificate of analysis
Every lot of P-21 Nasal Spray is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity (raw material): ≥99% by HPLC with mass-spectrometric identity confirmation — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about P-21 Nasal Spray
Why buy the spray instead of the vial?
P-21 has limited aqueous solubility because of its adamantane group, so preparing it from powder requires a co-solvent step and precipitation checks at the working dilution. The spray arrives already formulated and verified, with a metered pump giving a repeatable dispensed volume.
Is a certificate of analysis available?
Yes. The raw material is HPLC-tested and mass-spec confirmed before formulation, and a lot-matched COA is available on request. This matters particularly for P-21, since published structural identifiers for the compound differ between suppliers and reference databases.
Does it need reconstitution?
No. The bottle ships pre-mixed and ready to dispense. Prime the pump into waste until the mist is consistent, then use as your protocol specifies. No weighing, dissolution or co-solvent preparation is required by the receiving laboratory.
How should it be stored?
Refrigerate at 2 to 8 °C, upright and away from light, and do not freeze the filled bottle — freeze-thaw risks precipitation given the compound's solubility profile. Warm to room temperature before priming, and keep the in-use window short once the seal is broken.
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