- ≥99% by HPLC per component
- Lot-matched certificate of analysis
- Ships next business day, tracked
Ipamorelin + GHRP-2
Two GHS-R1a secretagogues co-lyophilized 1:1 in a 10 mg vial
- FormCo-lyophilized powder blend, sealed glass vial with crimped stopper
- Research areasGHS-R1a pharmacology, secretagogue potency and selectivity, somatotroph reserve, cortisol and prolactin cross-reactivity, IGF-1 axis
Overview
This vial holds two growth hormone secretagogues that act at the same receptor but were designed with different selectivity profiles. Ipamorelin is a pentapeptide with a C-terminal amide, sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2, built from unnatural residues including 2-aminoisobutyric acid and D-2-naphthylalanine. GHRP-2, also catalogued as pralmorelin, is the second-generation hexapeptide of the growth hormone-releasing peptide series, sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2. Both are agonists at the growth hormone secretagogue receptor 1a, the ghrelin receptor.
Because both components act at the same receptor, the vial is not a two-receptor design in the way GHRH-plus-GHRP combinations are; what it offers is the pair most often compared directly, held in a single preparation. The published contrast is selectivity against potency. Ipamorelin is described as releasing growth hormone with little accompanying cortisol, ACTH or prolactin response, while GHRP-2 is generally reported as the stronger releaser on a molar basis with more cross-reactivity at other pituitary outputs. Here the masses are close enough that the 1:1 mass fill of 5 mg each is near 1.15:1 in molar terms, an unusually clean comparison for a blend. Reconstitution is in bacteriostatic or sterile water, added down the vial wall and swirled rather than shaken.
Specifications
Identity
- Peptide class
- Two growth hormone-releasing peptides (GHRPs), both GHS-R1a agonists
Supply & purity
- Form
- Co-lyophilized powder blend, sealed glass vial with crimped stopper
- Purity
- ≥99% by HPLC per component; lot-matched COA available
- Available sizes
- 10 mg total — 5 mg Ipamorelin / 5 mg GHRP-2
- Solubility
- Bacteriostatic or sterile water
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light, used within the study window
Additional detail
- Components
- Ipamorelin and GHRP-2 (pralmorelin)
- Blend ratio
- 1:1 by mass
- Ipamorelin CAS number
- 170851-70-4
- Ipamorelin formula and mass
- C38H49N9O5, 711.85 g/mol
- Ipamorelin sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
- GHRP-2 CAS number
- 158861-67-7
- GHRP-2 formula and mass
- C45H55N9O6, 817.97 g/mol
- GHRP-2 sequence
- D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
- Also known as
- GHRP-2 is also catalogued as pralmorelin, KP-102 or GPA-748
- Primary target
- Growth hormone secretagogue receptor 1a (ghrelin receptor)
- Research areas
- GHS-R1a pharmacology, secretagogue potency and selectivity, somatotroph reserve, cortisol and prolactin cross-reactivity, IGF-1 axis
Working out the concentration
Reconstitution is where the arithmetic lives. The same vial made up with 1 mL or with 3 mL of diluent gives three-fold different numbers, which is why a reconstitution volume calculator is more use here than a fixed table: enter the vial mass and your diluent volume and read the concentration back.
Certificate of analysis
Every lot of Ipamorelin + GHRP-2 is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC per component — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Ipamorelin + GHRP-2
How much of each peptide is in the vial?
The 10 mg fill is a 1:1 blend — 5 mg of Ipamorelin and 5 mg of GHRP-2. Because the masses are equal, a single reconstitution calculation gives the concentration of both. Exact loading is stated on the label and on the lot-matched certificate of analysis.
Do these two peptides act on different receptors?
No — both are agonists at the growth hormone secretagogue receptor 1a, the ghrelin receptor. That is what distinguishes this blend from GHRH-analogue combinations such as CJC-1295 with a GHRP, where two genuinely separate receptors on the same somatotroph are engaged.
What is the difference between Ipamorelin and GHRP-2?
Selectivity versus potency. Ipamorelin is a pentapeptide widely described as the most selective classic GHRP, with little reported effect on cortisol and prolactin. GHRP-2 is a hexapeptide generally reported as the more potent releaser on a molar basis, with more cross-reactivity at other pituitary outputs.
What documentation comes with the vial?
A lot-matched certificate of analysis covering both peptides, each reported separately with HPLC purity of at least 99% and mass-spectrometric identity confirmation. Quote the lot number printed on the vial when requesting the document.
Which diluent should be used?
Bacteriostatic water is standard for multi-draw laboratory preparations because the benzyl alcohol preservative supports repeated septum entry. Sterile water is appropriate for a single-use solution. Add the diluent down the vial wall, swirl rather than shake, and keep the reconstituted vial refrigerated.
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