- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Adipotide (FTPP)
Peptidomimetic FTPP conjugate studied in adipose-vasculature targeting models
- FormLyophilized powder in a sealed glass vial
- Mol. weight≈2611.20 g/mol (trifluoroacetate salt content varies by lot)
- Research areasAdipose vascular targeting, ligand-directed peptide delivery, prohibitin biology, tumour-homing constructs
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Adipotide, also written FTPP (fat-targeted proapoptotic peptide), is a synthetic peptidomimetic built from two functional halves joined into a single molecule. One half is a cyclic nine-residue homing motif, CKGGRAKDC, identified by phage-display screening as a binder of a prohibitin-1 / annexin A2 complex reported on the endothelium of white adipose tissue. The other half is D(KLAKLAK)2, an amphipathic sequence assembled from D-amino acids that disrupts mitochondrial membranes once it reaches the inside of a cell. The design intent described in the literature is address-plus-payload: the homing motif supplies vascular selectivity, the effector domain supplies the activity.
Specifications
Identity
- CAS number
- 859216-15-2
- Molecular weight
- ≈2611.20 g/mol (trifluoroacetate salt content varies by lot)
Supply & purity
- Form
- Lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg
- Solubility
- Sterile or bacteriostatic water; dilute buffers are commonly used for working solutions
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C for short-term use; aliquot and freeze at −20 °C for longer holds
Additional detail
- Construct
- CKGGRAKDC-GG-D(KLAKLAK)2 — cyclic homing motif joined through a glycine linker to a pro-apoptotic domain
- Compound class
- Chimeric peptidomimetic (vascular-homing peptide plus membrane-disrupting effector)
- Homing motif
- CKGGRAKDC, reported to recognise a prohibitin-1 / annexin A2 complex on white adipose endothelium
- Effector domain
- D(KLAKLAK)2, an amphipathic D-amino acid sequence that perturbs mitochondrial membranes
- Research areas
- Adipose vascular targeting, ligand-directed peptide delivery, prohibitin biology, tumour-homing constructs
Questions about Adipotide (FTPP)
What is Adipotide (FTPP)?
It is a synthetic peptidomimetic that links a cyclic CKGGRAKDC homing motif to a D(KLAKLAK)2 membrane-disrupting domain. The design is described in the literature as a way to direct a cytotoxic effector toward the vasculature of white adipose tissue for experimental purposes.
Is Adipotide a GLP-1 or fat-loss peptide?
No. It does not act at the GLP-1 receptor and does not signal through lipolytic pathways. Its published rationale concerns vascular targeting via prohibitin, which makes it mechanistically unrelated to incretin analogues or growth-hormone fragments despite appearing in similar research categories.
What purity and documentation do you supply?
Every lot is purified to ≥99% by HPLC and released with a lot-matched certificate of analysis showing purity and identity data. Request the COA for your specific lot number and it will be sent as a PDF.
What sizes are available?
Adipotide is stocked as 2 mg and 5 mg lyophilized vials. Both are sealed glass vials shipped from a United States facility with the lot number printed on the label.
How should it be stored?
Keep the lyophilized powder at −20 °C, sealed and away from light and moisture. Once reconstituted, hold the solution at 2–8 °C for near-term work or aliquot and freeze at −20 °C so the material is not repeatedly thawed.
Can I buy Adipotide online for personal use?
No. This listing is a research reagent sold for laboratory use only. It is not a supplement, drug or cosmetic, and it must not be administered to humans or animals outside a properly authorised research setting.
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