- Analytically tested; certificate of analysis available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Tesofensine
Triple monoamine reuptake inhibitor supplied as 0.5 mg research capsules
- FormOral-format capsules, 0.5 mg per capsule, in a sealed bottle
- Research areasMonoamine transporter pharmacology, feeding behavior, reward and motivation circuits
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Tesofensine is a synthetic small molecule that inhibits the presynaptic reuptake transporters for norepinephrine, dopamine and serotonin. It is not a peptide, despite frequently being listed among them. The compound was originally developed as a candidate for neurodegenerative indications, where trials did not meet their endpoints, and its later research interest came from appetite and body-weight observations recorded during that earlier work.
As a research compound it is useful precisely because it engages all three monoamine transporters rather than one. Laboratories use it in transporter-binding and uptake-inhibition assays to establish relative affinity across NET, DAT and SERT, in microdialysis studies measuring extracellular monoamine concentrations in specific brain regions, and in rodent feeding-behavior work where reduced intake can be traced to particular neurotransmitter systems using selective antagonists.
Specifications
Identity
- CAS number
- 402856-42-2
Supply & purity
- Form
- Oral-format capsules, 0.5 mg per capsule, in a sealed bottle
- Purity
- Analytically tested; certificate of analysis available
- Available sizes
- 30 capsules, 60 capsules
Additional detail
- Compound class
- Small-molecule triple monoamine reuptake inhibitor (non-peptide)
- Molecular targets
- Norepinephrine, dopamine and serotonin transporters (NET, DAT, SERT)
- Research areas
- Monoamine transporter pharmacology, feeding behavior, reward and motivation circuits
- Storage
- Room temperature, sealed, dry and protected from light
- Handling note
- Centrally active compound; handle with standard controlled-laboratory precautions
Questions about Tesofensine
Is tesofensine a peptide?
No. It is a small-molecule triple monoamine reuptake inhibitor. It is frequently listed alongside metabolic peptides because of overlapping research interest in food intake, but its mechanism and chemistry are entirely different from the peptides in this catalog.
Which transporters does it act on?
Norepinephrine, dopamine and serotonin transporters — NET, DAT and SERT. The relative affinity across those three is the pharmacological feature that distinguishes it from selective reuptake inhibitors and drives the behavioral profile reported in animal studies.
What form is it supplied in?
As 0.5 mg capsules in sealed bottles of 30 or 60. This differs from most items in the catalog, which are lyophilized powders in vials, so no reconstitution step is involved for the material as supplied.
What documentation is available?
A certificate of analysis for the supplied lot is available on request, covering identity and purity. Keeping that document with your experimental record maintains traceability between analytical data and the material actually used.
Can these capsules be taken?
No. This product is supplied strictly as a research chemical for laboratory use. It is not a medicine, is not dispensed under a prescription and is not for human or veterinary consumption. We provide no dosing, protocol or administration guidance.
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