- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
Lipo-C (MIC + B12 + L-Carnitine)
MIC, vitamin B12 and L-carnitine lipotropic solution in 10 mL and 30 mL vials
- Research areasFatty-acid oxidation, mitochondrial substrate transport, one-carbon metabolism
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
L-carnitine is the component that changes the biochemical profile of the mixture. It is the obligatory carrier in the carnitine shuttle: carnitine palmitoyltransferase 1 on the outer mitochondrial membrane converts long-chain acyl-CoA to acylcarnitine, a translocase moves it across the inner membrane, and CPT2 regenerates acyl-CoA inside the matrix for beta-oxidation. Without that shuttle, long-chain fatty acids cannot reach the site where they are oxidized, which places carnitine at a genuine rate-influencing step rather than a peripheral one.
Specifications
Supply & purity
- Available sizes
- 10 mL, 30 mL
Additional detail
- Composition
- Methionine, inositol, choline (MIC), cyanocobalamin (vitamin B12) and L-carnitine
- Product class
- Lipotropic nutrient solution with carnitine (non-peptide)
- Appearance
- Clear deep pink to red solution; colour derives from cobalamin
- L-carnitine
- Quaternary ammonium compound; carrier in the CPT1/CPT2 mitochondrial fatty-acid shuttle
- Methionine
- Essential sulfur amino acid; precursor of S-adenosylmethionine
- Inositol
- Carbocyclic sugar; backbone of phosphatidylinositol signaling lipids
- Choline
- Quaternary ammonium nutrient; required for phosphatidylcholine synthesis
- Cyanocobalamin
- Cobalt corrinoid form of vitamin B12; cofactor precursor for methionine synthase
- Research areas
- Fatty-acid oxidation, mitochondrial substrate transport, one-carbon metabolism
- Storage
- 2–8 °C, protected from light; cobalamin is photosensitive
Questions about Lipo-C (MIC + B12 + L-Carnitine)
What does Lipo-C add over Lipo-B?
L-carnitine. Lipo-B contains methionine, inositol, choline and vitamin B12; Lipo-C adds carnitine, the carrier that moves long-chain fatty acids across the inner mitochondrial membrane so they can be oxidized.
Why is carnitine mechanistically interesting?
It sits at an obligatory step. Long-chain acyl-CoA cannot enter mitochondria without conversion to acylcarnitine by CPT1, and CPT1 is itself inhibited by malonyl-CoA, which ties fatty-acid oxidation to the fed and fasted state of the cell.
Does adding carnitine always increase fat oxidation?
Not necessarily. In carnitine-deficient systems the effect is clear, but in tissue with adequate carnitine the shuttle is usually not rate-limiting. Careful studies measure baseline carnitine and acylcarnitine profiles before interpreting any change.
How should it be stored?
Refrigerate at 2–8 °C, protected from light, and do not freeze. The cobalamin component is photosensitive, so keep the vial in its carton or a dark container and note the date the vial was first entered.
Related
