- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
Lipo-B (MIC + B12)
MIC and vitamin B12 lipotropic solution in 10 mL and 30 mL vials
- Research areasOne-carbon metabolism, hepatic lipid export, methyl-donor availability
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Each component has a defined role in one-carbon and lipid metabolism. Methionine is an essential sulfur amino acid and the precursor of S-adenosylmethionine, the cell's principal methyl donor. Choline is a quaternary ammonium compound required for phosphatidylcholine synthesis, which in turn is needed for hepatic export of triglycerides in very-low-density lipoproteins; choline deficiency is the classic experimental route to hepatic steatosis in rodent models. Inositol is a carbocyclic sugar that forms the backbone of phosphatidylinositol and its phosphorylated signaling derivatives. Cyanocobalamin serves as the cofactor precursor for methionine synthase and methylmalonyl-CoA mutase, linking B12 status directly to methylation capacity and to propionate metabolism.
Specifications
Supply & purity
- Available sizes
- 10 mL, 30 mL
Additional detail
- Composition
- Methionine, inositol, choline (MIC) with cyanocobalamin (vitamin B12)
- Product class
- Lipotropic nutrient solution (non-peptide)
- Appearance
- Clear deep pink to red solution; colour derives from cobalamin
- Methionine
- Essential sulfur amino acid; precursor of S-adenosylmethionine
- Inositol
- Carbocyclic sugar; backbone of phosphatidylinositol signaling lipids
- Choline
- Quaternary ammonium nutrient; required for phosphatidylcholine synthesis
- Cyanocobalamin
- Cobalt corrinoid form of vitamin B12; cofactor precursor for methionine synthase
- Research areas
- One-carbon metabolism, hepatic lipid export, methyl-donor availability
- Storage
- 2–8 °C, protected from light; cobalamin is photosensitive
- Documentation
- Certificate of analysis available for the supplied lot
Questions about Lipo-B (MIC + B12)
What does MIC stand for?
Methionine, inositol and choline — the three lipotropic components combined in this solution. Lipo-B pairs that trio with cyanocobalamin, the stable vitamin B12 form, which is what gives the solution its deep pink colour.
How is it different from Lipo-C?
Lipo-C contains the same MIC and B12 base plus L-carnitine, the carrier that transports long-chain fatty acids into mitochondria. The added component is what distinguishes the two formulations in comparative research designs.
Why must it be kept away from light?
Cobalamin is photosensitive and degrades with prolonged light exposure. Because the vitamin gives the solution its colour, visible fading is a practical indicator that the material has been stored improperly and should be assessed before use.
What documentation is provided?
A certificate of analysis for the supplied lot is available on request. Keeping it with your experimental record maintains traceability between the analytical data and the specific vial used, which matters for multi-component solutions.
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