- ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
Bronchogen
Ala-Glu-Asp-Leu (AEDL) tetrapeptide used in bronchial-tissue research models
- FormLyophilized powder in a sealed glass vial
- Mol. weight446.46 g/mol
- Research areasBronchial epithelial culture, lung tissue models, epithelial differentiation markers, gene expression
Overview
Bronchogen is a synthetic tetrapeptide with the sequence L-alanyl-L-glutamyl-L-aspartyl-L-leucine (Ala-Glu-Asp-Leu, or AEDL). Within the Khavinson short-peptide bioregulator series it is the sequence assigned to bronchial and lung tissue, following the same development path as the rest of the family: an organ-derived peptide preparation was studied first, a short candidate sequence identified, and the defined synthetic tetrapeptide adopted as the research material.
AEDL is the hydrophobic member of the Ala-Glu-Asp trio. Where Cortagen ends in proline and Cardiogen in arginine, Bronchogen ends in leucine, a branched aliphatic residue with no charge. On a four-residue backbone that single substitution measurably changes solubility profile, reversed-phase retention, and the balance between polar and nonpolar surface area, which is why the three peptides behave differently in the same analytical method despite sharing three quarters of their sequence.
Reported laboratory work with AEDL centres on bronchial epithelial cell cultures, lung tissue preparations from rodents, and expression studies covering epithelial differentiation and surfactant-related markers. Our Bronchogen ships as a 20 mg lyophilized vial, synthesised by solid-phase peptide synthesis and HPLC purified to a ≥99% specification, with a lot-matched certificate of analysis available. It is offered strictly for laboratory research.
Specifications
Identity
- Molecular formula
- C18H30N4O9
- Molecular weight
- 446.46 g/mol
- Amino acid sequence
- Ala-Glu-Asp-Leu (AEDL), linear tetrapeptide
- Peptide class
- Khavinson short-peptide bioregulator (tetrapeptide)
Supply & purity
- Form
- Lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 20 mg
- Solubility
- Bacteriostatic or sterile water; readily soluble in aqueous buffers
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Tissue association
- Bronchial and lung peptide preparations
- Research areas
- Bronchial epithelial culture, lung tissue models, epithelial differentiation markers, gene expression
- Sequence relationship
- Shares the Ala-Glu-Asp core with Cortagen (AEDP) and Cardiogen (AEDR)
Working out the concentration
Bronchogen ships as a lyophilized powder, so nothing on this page can state a concentration: the figure you work with is the one you create when you add diluent. Put the vial mass and the volume you intend to use into the peptide reconstitution calculator and it returns mg/mL, mcg/mL and the mass sitting at each mark on a U-100 syringe.
Where a method is written in molar terms instead, the molecular weight above — 446.46 g/mol — is the input the molarity calculator needs.
Certificate of analysis
Every lot of Bronchogen is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Bronchogen
What is Bronchogen?
Bronchogen is the synthetic tetrapeptide Ala-Glu-Asp-Leu (AEDL) from the Khavinson short-peptide bioregulator series, associated in that literature with bronchial and lung tissue. It is supplied as a lyophilized research chemical for laboratory work only.
How is quality verified?
Each lot is analysed by HPLC against a ≥99% purity specification, and a lot-matched certificate of analysis is available on request. The COA lists the batch identifier, purity result, identity confirmation, and physical description of the material supplied.
Why does the leucine residue matter?
Leucine is a branched, uncharged, hydrophobic side chain, which makes AEDL the least polar peptide of the Ala-Glu-Asp trio. That changes solubility and reversed-phase retention, so analytical methods tuned for Cardiogen or Cortagen often need adjusting.
Why is no CAS number listed?
No widely recognised CAS registry entry exists for this sequence, so we leave the field blank rather than publish an unverified value. Identity is defined by the amino acid sequence, molecular formula, and weight, confirmed on the lot COA.
How should it be stored?
Keep the unopened lyophilized vial at −20 °C, protected from light and moisture. Once reconstituted, hold the solution at 2–8 °C for the planned study window, or freeze single-use aliquots to avoid repeated freeze-thaw cycles.
