- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Cardiogen
Ala-Glu-Asp-Arg (AEDR) tetrapeptide used in cardiac-tissue research models
- FormLyophilized powder in a sealed glass vial
- Mol. weight489.48 g/mol
- Research areasCardiomyocyte culture, stem-cell differentiation models, myocardial tissue, gene expression
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Cardiogen is a synthetic tetrapeptide with the sequence L-alanyl-L-glutamyl-L-aspartyl-L-arginine (Ala-Glu-Asp-Arg, or AEDR). It is the cardiac member of the Khavinson short-peptide bioregulator series, developed along the same lines as the rest of the family: heart tissue peptide preparations were studied first, a short candidate sequence was identified, and the synthetic tetrapeptide replaced the extract as a defined and reproducible research material.
Arginine at the fourth position gives Cardiogen a strongly basic side chain that the other Ala-Glu-Asp peptides lack. At neutral pH the guanidinium group carries a positive charge, so AEDR is zwitterionic in a different way from Cortagen or Bronchogen and interacts differently with anionic surfaces, nucleic acids, and ion-exchange media. Researchers doing chromatography or binding work with the series routinely note this, since retention behaviour and apparent affinity can diverge sharply from the neutral or hydrophobic variants.
Published work involving AEDR includes cardiomyocyte and stem-cell differentiation cultures, isolated cardiac tissue preparations, expression studies on a limited gene panel, and rodent experiments examining myocardial tissue with age. Our Cardiogen is supplied as a 20 mg lyophilized vial produced by SPPS and purified by HPLC to a ≥99% specification, with a lot-matched certificate of analysis. It is sold for laboratory research only.
Specifications
Identity
- Molecular formula
- C18H31N7O9
- Molecular weight
- 489.48 g/mol
- Amino acid sequence
- Ala-Glu-Asp-Arg (AEDR), linear tetrapeptide
- Peptide class
- Khavinson short-peptide bioregulator (tetrapeptide)
Supply & purity
- Form
- Lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 20 mg
- Solubility
- Bacteriostatic or sterile water; readily soluble in aqueous buffers
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Tissue association
- Heart and myocardial peptide preparations
- Research areas
- Cardiomyocyte culture, stem-cell differentiation models, myocardial tissue, gene expression
- Sequence relationship
- Shares the Ala-Glu-Asp core with Cortagen (AEDP) and Bronchogen (AEDL)
Questions about Cardiogen
What is Cardiogen?
Cardiogen is the synthetic tetrapeptide Ala-Glu-Asp-Arg (AEDR) from the Khavinson short-peptide bioregulator series, associated in that literature with heart tissue. It is supplied as a lyophilized research chemical for laboratory investigation only.
How is purity confirmed?
Each batch is analysed by HPLC against a ≥99% purity specification, and a lot-matched certificate of analysis is available on request. The COA records the batch number, purity result, identity confirmation, and physical description of the material.
Why is no CAS number shown?
No widely recognised CAS registry entry exists for this sequence, so the field is left blank rather than filled with an unverified value. Identity rests on the sequence, molecular formula, and weight, all confirmed against the lot certificate of analysis.
What makes the arginine residue significant?
Arginine carries a positively charged guanidinium group at neutral pH, which no other Ala-Glu-Asp peptide in the series has. It changes how the molecule behaves on chromatography columns and in binding assays, so methods often need adjusting for this peptide.
How should the vial be stored?
Keep the unopened lyophilized vial at −20 °C, away from light and moisture. After reconstitution store the solution at 2–8 °C for the planned study window, or freeze single-use aliquots if the material is needed over a longer period.
