- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Livagen
Lys-Glu-Asp-Ala (KEDA) tetrapeptide used in hepatic and chromatin research models
- FormLyophilized powder in a sealed glass vial
- Mol. weight461.47 g/mol
- Research areasChromatin decondensation, lymphocyte cytogenetics, hepatocyte culture, liver tissue models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Livagen is a synthetic tetrapeptide with the sequence L-lysyl-L-glutamyl-L-aspartyl-L-alanine (Lys-Glu-Asp-Ala, or KEDA). It belongs to the Khavinson short-peptide bioregulator series and is the sequence associated with liver tissue preparations. Like the rest of the family it began as a tissue-derived peptide extract and was then reduced to a defined synthetic sequence so that experiments could be run on a single characterised molecule.
KEDA is notable within the series because it appears prominently in the cytogenetic literature rather than only in organ-focused studies. Several published experiments applied it to cultured human lymphocytes, including cells from older donors, and reported changes in heterochromatin decondensation and in the activity of ribosomal gene regions assessed by staining. That work is the most frequently cited evidence offered for the claim that these ultrashort peptides reach the nucleus and act on chromatin structure.
Beyond the chromatin work, laboratories use Livagen in hepatocyte cultures and rodent liver models where markers of tissue structure, protein synthesis, and gene expression are measured. Our material ships as a 20 mg lyophilized vial, synthesised by SPPS and HPLC purified to a ≥99% specification, with a lot-matched certificate of analysis available on request. It is supplied for laboratory research only.
Specifications
Identity
- Molecular formula
- C18H31N5O9
- Molecular weight
- 461.47 g/mol
- Amino acid sequence
- Lys-Glu-Asp-Ala (KEDA), linear tetrapeptide
- Peptide class
- Khavinson short-peptide bioregulator (tetrapeptide)
Supply & purity
- Form
- Lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 20 mg
- Solubility
- Bacteriostatic or sterile water; readily soluble in aqueous buffers
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Tissue association
- Liver peptide preparations
- Research areas
- Chromatin decondensation, lymphocyte cytogenetics, hepatocyte culture, liver tissue models
- Sequence relationship
- Vesugen (KED) extended by a C-terminal alanine residue
Questions about Livagen
What is Livagen?
Livagen is the synthetic tetrapeptide Lys-Glu-Asp-Ala (KEDA) from the Khavinson short-peptide bioregulator series, associated in that literature with liver tissue. It is supplied as a lyophilized research chemical for laboratory investigation only.
Is the purity independently documented?
Yes. Every lot is tested by HPLC against a ≥99% purity specification and a lot-matched certificate of analysis is available, recording the batch identifier, purity result, identity confirmation, and physical description of the powder.
Why is Livagen cited in chromatin research?
Published cytogenetic experiments applied KEDA to cultured human lymphocytes and reported increased heterochromatin decondensation and nucleolar organiser activity, particularly in cells from older donors. That work is the most frequently referenced support for the chromatin hypothesis behind this peptide family.
Why is no CAS number listed?
No widely accepted CAS registry entry is available for this sequence, so the field is left blank rather than filled with an unverified number. Identity is defined by sequence, molecular formula, and weight, all confirmed on the lot COA.
What does research use only mean?
The peptide is sold strictly for laboratory research by qualified professionals. It is not approved as a drug, supplement, or cosmetic, and no human or veterinary administration guidance is provided or implied with the product.
How should it be stored?
Store the unopened lyophilized vial at −20 °C, away from light and moisture. After reconstitution keep the solution refrigerated at 2–8 °C for the planned study window, or freeze single-use aliquots for longer-term storage.
