- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Dihexa
Angiotensin IV-derived peptidomimetic studied in HGF/c-Met synaptogenesis models
- FormLyophilized powder in a sealed glass vial
- Research areasSynaptogenesis, dendritic spine density, hippocampal culture models, cognitive impairment models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Dihexa is a small synthetic peptidomimetic developed from angiotensin IV research at Washington State University. Its full chemical name, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, describes the design: a two-residue core flanked by a hexanoyl chain at one end and an aminohexanoic amide at the other. Those non-standard, lipophilic ends are the point — they were added to make the molecule metabolically stable and far more lipid-soluble than a conventional short peptide.
Specifications
Identity
- CAS number
- 1401708-83-5
Supply & purity
- Form
- Lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 10 mg, 20 mg
- Solubility
- Poorly water-soluble; a co-solvent such as DMSO is commonly used before dilution
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
Additional detail
- Chemical name
- N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
- Compound class
- Angiotensin IV-derived peptidomimetic (dipeptide core with lipophilic termini)
- Primary research target
- HGF / c-Met receptor signaling
- Research areas
- Synaptogenesis, dendritic spine density, hippocampal culture models, cognitive impairment models
- Synthesis
- Solid-phase synthesis with preparative HPLC purification
- Storage (in solution)
- 2–8 °C short term; −20 °C in aliquots for longer storage
Questions about Dihexa
Is Dihexa actually a peptide?
Not in the conventional sense. It is a peptidomimetic built on a two-residue core with a hexanoyl group and an aminohexanoic amide at the termini. Those non-amino-acid components give it protease resistance and high lipophilicity, so it behaves more like a small drug-like molecule than a standard research peptide.
Why does Dihexa need a co-solvent?
The lipophilic termini that make the molecule stable also make it poorly soluble in water. Most laboratories dissolve it first in a compatible organic solvent such as DMSO, then dilute into buffer, verifying that nothing precipitates at the working concentration used in the assay.
What purity documentation is included?
Every lot is analyzed by HPLC for purity and mass spectrometry for identity, with a lot-matched certificate of analysis available on request. Because published formula and mass values for this compound vary between sources, the COA is the authoritative record for the material you receive.
What sizes are offered?
Dihexa is supplied in 10 mg and 20 mg lyophilized vials. Given the co-solvent stock workflow most laboratories use, the larger vial helps keep an extended experimental series on a single lot and a single stock preparation.
Can Dihexa be used outside a laboratory?
No. It is sold strictly for research use, is not approved for human or veterinary administration, and is not a drug or supplement. Its c-Met-linked mechanism also raises unresolved proliferation questions, which is one more reason handling should stay within a controlled research setting.
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