- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
PE-22-28
Spadin-derived heptapeptide studied as a TREK-1 potassium channel blocker
- FormLyophilized white powder in a sealed glass vial
- Mol. weight773.89 g/mol
- Research areasElectrophysiology, mood-related behavioral models, hippocampal neurogenesis and synaptic markers
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
PE-22-28 is a synthetic heptapeptide corresponding to residues 22-28 of spadin, a peptide released from the propeptide domain of sortilin. Spadin itself attracted attention as a natural blocker of TREK-1, a two-pore-domain potassium channel that has been genetically linked to mood regulation in rodent studies. PE-22-28 is the shortened fragment retained after investigators mapped which portion of spadin carried the channel-blocking activity.
MyPeptide supplies PE-22-28 as a 10 mg lyophilized vial for laboratory research — patch-clamp and receptor assays, analytical method work, and approved animal studies. Each lot is HPLC-purified with mass-spec identity confirmation and a lot-matched certificate of analysis available on request. It ships from a United States facility. This is a research chemical and is not a drug, supplement or consumer product.
Specifications
Identity
- CAS number
- 1234388-01-0
- Molecular formula
- C35H55N11O9
- Molecular weight
- 773.89 g/mol
- Amino acid sequence
- Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR), linear with unmodified termini
- Peptide class
- Synthetic heptapeptide ion-channel blocker fragment
Supply & purity
- Form
- Lyophilized white powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Solubility
- Soluble in bacteriostatic water and sterile water
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C; aliquot to avoid repeated freeze-thaw
Additional detail
- Available size
- 10 mg
- Primary research target
- TREK-1 (KCNK2) two-pore-domain potassium channel
- Research areas
- Electrophysiology, mood-related behavioral models, hippocampal neurogenesis and synaptic markers
Questions about PE-22-28
What is PE-22-28 a fragment of?
It corresponds to residues 22 through 28 of spadin, a peptide generated from the propeptide region of sortilin. Researchers narrowed spadin down to this heptapeptide while mapping which part of the sequence carried TREK-1 channel-blocking activity in electrophysiological assays.
Is the peptide third-party tested?
Yes. Each lot is analyzed by reversed-phase HPLC for purity and by mass spectrometry for identity, with a lot-matched certificate of analysis available on request. The COA reports purity, observed mass and analysis date for the exact batch shipped.
What is TREK-1 and why is it studied?
TREK-1 is a two-pore-domain background potassium channel encoded by KCNK2. Rodent genetic studies linked its absence to a mood-related behavioral phenotype, which made pharmacological blockade an active research question and made spadin-derived fragments useful laboratory tools.
How stable is PE-22-28 in solution?
It is a short linear peptide with unmodified termini, so it is more susceptible to exopeptidase cleavage than acetylated or amidated analogs. Keep reconstituted material refrigerated at 2–8 °C, aliquot for single use, and keep working samples cold during assay sessions.
What size does it ship in?
PE-22-28 is supplied as a single 10 mg lyophilized vial. That quantity generally covers a full concentration-response series in cell-based electrophysiology work with material left over for analytical confirmation.
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