- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Semax
ACTH(4-10) heptapeptide analog for neurotrophic and cognition research
- FormLyophilized white powder in a sealed glass vial
- Mol. weight813.93 g/mol
- Research areasBDNF/NGF expression, attention and memory models, cerebral ischemia, oxidative stress
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Semax is a synthetic heptapeptide built around the 4-10 fragment of adrenocorticotropic hormone (ACTH), with the tripeptide Pro-Gly-Pro added to the C-terminus. That tail is the whole design idea: the native ACTH(4-10) fragment is cleaved within minutes in plasma, while the proline-rich extension slows enzymatic breakdown substantially. Critically, the truncation removes the portion of ACTH responsible for corticotropic activity, so Semax is studied as a neuroactive peptide rather than a hormonal one.
This listing supplies Semax as a lyophilized powder in a sealed vial for laboratory work — in vitro assays, analytical method development, and animal model research conducted under an approved protocol. Every lot is HPLC-tested with a lot-matched certificate of analysis available on request. Semax is sold strictly for research use and is not a drug, supplement, or food product.
Specifications
Identity
- CAS number
- 80714-61-0
- Molecular formula
- C37H51N9O10S
- Molecular weight
- 813.93 g/mol
- Amino acid sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Peptide class
- Synthetic ACTH(4-10) heptapeptide analog (regulatory neuropeptide)
Supply & purity
- Form
- Lyophilized white powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg
- Solubility
- Readily soluble in bacteriostatic water and sterile water
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C; use within the planned study window
Additional detail
- Research areas
- BDNF/NGF expression, attention and memory models, cerebral ischemia, oxidative stress
- Synthesis
- Solid-phase peptide synthesis, purified by preparative HPLC
Questions about Semax
Is this Semax third-party tested?
Yes. Every lot is analyzed by HPLC for purity and by mass spectrometry for identity, and a lot-matched certificate of analysis is available on request. The COA reports purity percentage, observed mass and the analysis date so you can tie documentation to the exact vial you received.
What is the difference between Semax and ACTH(4-10)?
Semax is ACTH(4-10) with a Pro-Gly-Pro extension on the C-terminus. That addition slows enzymatic degradation considerably in published animal pharmacokinetic work. The fragment also lacks the region of ACTH associated with corticotropic activity, which is why the literature describes it as a non-hormonal regulatory peptide.
Which sizes are available?
Semax is supplied as 5 mg and 10 mg lyophilized vials. Laboratories running short in vitro assays typically choose the 5 mg vial, while longer studies favor 10 mg to keep the whole series within one lot and one COA.
How should the vial be stored?
Keep lyophilized powder at −20 °C away from light and humidity, where it is stable for extended periods. After reconstitution, store at 2–8 °C and use within your planned study window. Aliquot rather than repeatedly freezing and thawing the same vial.
How is Semax dissolved for laboratory use?
The peptide dissolves readily in bacteriostatic or sterile water. Add solvent slowly along the vial wall and swirl gently until the cake clears. Working concentrations depend entirely on your assay design; we do not provide dosing or administration guidance of any kind.
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