- ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
Semax Peptide
ACTH(4-10) heptapeptide analog for neurotrophic and cognition research
- FormLyophilized white powder in a sealed glass vial
- Mol. weight813.93 g/mol
- Research areasBDNF/NGF expression, attention and memory models, cerebral ischemia, oxidative stress
Overview
Semax is a synthetic heptapeptide built around the 4-10 fragment of adrenocorticotropic hormone (ACTH), with the tripeptide Pro-Gly-Pro added to the C-terminus. That tail is the whole design idea: the native ACTH(4-10) fragment is cleaved within minutes in plasma, while the proline-rich extension slows enzymatic breakdown substantially. Critically, the truncation removes the portion of ACTH responsible for corticotropic activity, so Semax is studied as a neuroactive peptide rather than a hormonal one.
This listing supplies Semax as a lyophilized powder in a sealed vial for laboratory work — in vitro assays, analytical method development, and animal model research conducted under an approved protocol. Every lot is HPLC-tested with a lot-matched certificate of analysis available on request. Semax is sold strictly for research use and is not a drug, supplement, or food product.
Specifications
Identity
- CAS number
- 80714-61-0
- Molecular formula
- C37H51N9O10S
- Molecular weight
- 813.93 g/mol
- Amino acid sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Peptide class
- Synthetic ACTH(4-10) heptapeptide analog (regulatory neuropeptide)
Supply & purity
- Form
- Lyophilized white powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg, 30 mg
- Solubility
- Readily soluble in bacteriostatic water and sterile water
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C; use within the planned study window
Additional detail
- Research areas
- BDNF/NGF expression, attention and memory models, cerebral ischemia, oxidative stress
- Synthesis
- Solid-phase peptide synthesis, purified by preparative HPLC
Working out the concentration
Reconstitution is where the arithmetic lives. The same vial made up with 1 mL or with 3 mL of diluent gives three-fold different numbers, which is why a reconstitution volume calculator is more use here than a fixed table: enter the vial mass and your diluent volume and read the concentration back.
If the protocol asks for a molar concentration, the molar concentration calculator converts between 813.93 g/mol, the mass you weigh out and the volume you dissolve it in.
Certificate of analysis
Every lot of Semax is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Semax
Is this Semax third-party tested?
Yes. Every lot is analyzed by HPLC for purity and by mass spectrometry for identity, and a lot-matched certificate of analysis is available on request. The COA reports purity percentage, observed mass and the analysis date so you can tie documentation to the exact vial you received.
What is the difference between Semax and ACTH(4-10)?
Semax is ACTH(4-10) with a Pro-Gly-Pro extension on the C-terminus. That addition slows enzymatic degradation considerably in published animal pharmacokinetic work. The fragment also lacks the region of ACTH associated with corticotropic activity, which is why the literature describes it as a non-hormonal regulatory peptide.
Which sizes are available?
Semax is supplied as 5 mg and 10 mg lyophilized vials. Laboratories running short in vitro assays typically choose the 5 mg vial, while longer studies favor 10 mg to keep the whole series within one lot and one COA.
How should the vial be stored?
Keep lyophilized powder at −20 °C away from light and humidity, where it is stable for extended periods. After reconstitution, store at 2–8 °C and use within your planned study window. Aliquot rather than repeatedly freezing and thawing the same vial.
How is Semax dissolved for laboratory use?
The peptide dissolves readily in bacteriostatic or sterile water. Add solvent slowly along the vial wall and swirl gently until the cake clears. Working concentrations depend entirely on your assay design; we do not provide dosing or administration guidance of any kind.
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