- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
N-Acetyl Semax Amidate
Terminally protected Semax analog for extended-stability research
- FormLyophilized white powder in a sealed glass vial
- Research areasPeptide stability, neurotrophic factor expression, attention and memory models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
N-Acetyl Semax Amidate, often abbreviated NA-Semax-Amidate or NASA, is a doubly protected derivative of Semax. Two chemical modifications are applied to the parent heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro: an acetyl group caps the free N-terminus and the C-terminal carboxyl is converted to a primary amide. Both changes are standard peptide-chemistry strategies for blocking exopeptidase attack, and both remove a charged terminus, which also alters the molecule's overall polarity.
The design intent behind these modifications is stability rather than a new mechanism. Researchers who work with terminally protected analogs are typically comparing degradation kinetics, plasma and tissue residence, and mucosal permeability against the unmodified parent. In the Semax family this comparison is of particular interest because the parent peptide already carries a Pro-Gly-Pro tail added for the same reason, so the amidated acetylated version represents a second layer of protection.
Supplied here as a 10 mg lyophilized vial for laboratory use — stability studies, analytical method development, in vitro assays and approved animal research. Each batch is HPLC-purified with a lot-matched certificate of analysis available. This is a research chemical: not a drug, not a supplement, and not for human or veterinary administration.
Specifications
Identity
- Amino acid sequence
- Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
- Peptide class
- Terminally protected synthetic ACTH(4-10) analog
Supply & purity
- Form
- Lyophilized white powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Solubility
- Soluble in bacteriostatic water and sterile water
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C; aliquot to avoid freeze-thaw cycles
Additional detail
- Available size
- 10 mg
- Parent peptide
- Semax — ACTH(4-10) analog, CAS 80714-61-0
- Modifications
- N-terminal acetyl cap; C-terminal primary amide
- Research areas
- Peptide stability, neurotrophic factor expression, attention and memory models
- Synthesis
- Solid-phase peptide synthesis with preparative HPLC purification
Questions about N-Acetyl Semax Amidate
How does this differ from standard Semax?
The backbone sequence is identical. This version adds an acetyl group at the N-terminus and converts the C-terminal acid to an amide. Both modifications block exopeptidase cleavage and remove a charged terminus, so the analog is studied primarily for stability and permeability characteristics rather than a different mechanism.
Is a certificate of analysis provided?
Yes. Every lot is HPLC-tested for purity and mass-spec confirmed for identity, with a lot-matched COA available on request. For modified analogs the observed mass is especially useful, since it confirms both the acetylation and the amidation are present.
What size is available?
This item ships as a single 10 mg lyophilized vial. That quantity suits comparative stability panels and in vitro assay series where the unmodified parent peptide is run alongside as a control.
How should it be stored after reconstitution?
Keep the solution at 2–8 °C, protected from light, and use it within your planned study window. Aliquot into single-use portions rather than repeatedly freezing and thawing a single vial, which degrades peptides regardless of terminal protection.
Can this be used as a supplement or medicine?
No. It is supplied strictly for laboratory research use, is not approved for human or veterinary administration, and is not a drug, food or supplement. Handling should be limited to qualified personnel working under an appropriate research protocol.
Which solvent is appropriate?
Bacteriostatic water is the standard benchtop choice, with sterile water used when a preservative-free solution is required. Add solvent slowly to the vial wall and allow the powder to dissolve without agitation. Concentrations are determined by your own experimental design.
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