- HPLC tested for purity and identity
- Lot-matched certificate of analysis
- Ships next business day, tracked
Research Compounds (SARMs & Small Molecules)
Enclomiphene Citrate — Research Liquid
Trans-isomer of clomiphene, a SERM studied in hypothalamic-pituitary-gonadal models
- FormResearch liquid in a sealed bottle with a graduated dispenser
- Mol. weight405.96 g/mol (free base)
- Research areasHypothalamic-pituitary-gonadal feedback, gonadotropin regulation, secondary hypogonadism models
Overview
Enclomiphene is the trans-isomer of clomiphene, a triphenylethylene selective estrogen receptor modulator. Clomiphene citrate as historically supplied is a mixture of two geometric isomers with markedly different pharmacology: zuclomiphene, the cis-isomer, behaves largely as an estrogen receptor agonist and has a long elimination half-life, while enclomiphene is the antagonist-leaning isomer with far faster clearance. Isolating the trans-isomer was pursued precisely to separate those profiles.
Mechanistically, enclomiphene antagonises estrogen receptors at the hypothalamus and pituitary, interrupting the negative feedback that estradiol exerts on gonadotropin-releasing hormone signalling. The consequence studied in the literature is increased luteinising hormone and follicle-stimulating hormone output, and downstream increases in endogenous testosterone in male models. That places it in a different category from the peptide secretagogues and gonadotropins it is often compared with, which act at their own receptors rather than by releasing feedback inhibition.
Specifications
Identity
- CAS number
- 7599-79-3 (enclomiphene citrate)
- Molecular formula
- C26H28ClNO (free base); supplied as the citrate salt
- Molecular weight
- 405.96 g/mol (free base)
Supply & purity
- Form
- Research liquid in a sealed bottle with a graduated dispenser
- Purity
- HPLC tested for purity and identity; lot-matched COA available
Additional detail
- Size and concentration
- 30 mL at 25 mg/mL
- Compound class
- Triphenylethylene selective estrogen receptor modulator (SERM) — not a peptide
- Isomer
- Trans-isomer (E) of clomiphene; the cis-isomer is zuclomiphene
- Molecular target
- Estrogen receptors, with antagonist-predominant activity at hypothalamic and pituitary sites
- Downstream axis
- GnRH pulsatility, LH and FSH secretion, gonadal steroidogenesis
- Research areas
- Hypothalamic-pituitary-gonadal feedback, gonadotropin regulation, secondary hypogonadism models
- Regulatory status
- Not approved for any indication; not a dietary supplement ingredient
- Storage
- Cool, dry and dark, tightly capped; refrigeration extends solution stability
Units and conversions
Capsule and troche strengths are stated per unit, so the figure a method needs is usually a conversion rather than a dilution. The mcg to mg converter handles the milligram-to-microgram step, and the millilitre arithmetic if you are working from a solution format instead.
Certificate of analysis
Every lot of Enclomiphene Citrate — Research Liquid is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: HPLC tested for purity and identity — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Enclomiphene Citrate — Research Liquid
How is enclomiphene different from clomiphene?
Clomiphene citrate is a mixture of two geometric isomers. Enclomiphene is the trans-isomer alone — the antagonist-leaning, faster-clearing component. The cis-isomer, zuclomiphene, is estrogenic and long-lived, and separating the two was the reason enclomiphene was developed as a distinct entity.
Is enclomiphene a peptide?
No. It is a non-peptide small molecule of the triphenylethylene class, chemically related to tamoxifen. It acts on estrogen receptors, whereas the peptides it is often compared with, such as gonadorelin or hCG, act at their own receptors within the same hormonal axis.
What documentation is provided?
Each lot is HPLC tested for purity and identity, with a lot-matched certificate of analysis available on request. Keeping that document with your study records maintains traceability between the characterised material and the data produced from it.
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