- HPLC tested for purity and identity; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Enclomiphene Citrate — Research Liquid
Trans-isomer of clomiphene, a SERM studied in hypothalamic-pituitary-gonadal models
- FormResearch liquid in a sealed bottle with a graduated dispenser
- Mol. weight405.96 g/mol (free base)
- Research areasHypothalamic-pituitary-gonadal feedback, gonadotropin regulation, secondary hypogonadism models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Enclomiphene is the trans-isomer of clomiphene, a triphenylethylene selective estrogen receptor modulator. Clomiphene citrate as historically supplied is a mixture of two geometric isomers with markedly different pharmacology: zuclomiphene, the cis-isomer, behaves largely as an estrogen receptor agonist and has a long elimination half-life, while enclomiphene is the antagonist-leaning isomer with far faster clearance. Isolating the trans-isomer was pursued precisely to separate those profiles.
Mechanistically, enclomiphene antagonises estrogen receptors at the hypothalamus and pituitary, interrupting the negative feedback that estradiol exerts on gonadotropin-releasing hormone signalling. The consequence studied in the literature is increased luteinising hormone and follicle-stimulating hormone output, and downstream increases in endogenous testosterone in male models. That places it in a different category from the peptide secretagogues and gonadotropins it is often compared with, which act at their own receptors rather than by releasing feedback inhibition.
Specifications
Identity
- CAS number
- 7599-79-3 (enclomiphene citrate)
- Molecular formula
- C26H28ClNO (free base); supplied as the citrate salt
- Molecular weight
- 405.96 g/mol (free base)
Supply & purity
- Form
- Research liquid in a sealed bottle with a graduated dispenser
- Purity
- HPLC tested for purity and identity; lot-matched COA available
Additional detail
- Size and concentration
- 30 mL at 25 mg/mL
- Compound class
- Triphenylethylene selective estrogen receptor modulator (SERM) — not a peptide
- Isomer
- Trans-isomer (E) of clomiphene; the cis-isomer is zuclomiphene
- Molecular target
- Estrogen receptors, with antagonist-predominant activity at hypothalamic and pituitary sites
- Downstream axis
- GnRH pulsatility, LH and FSH secretion, gonadal steroidogenesis
- Research areas
- Hypothalamic-pituitary-gonadal feedback, gonadotropin regulation, secondary hypogonadism models
- Regulatory status
- Not approved for any indication; not a dietary supplement ingredient
- Storage
- Cool, dry and dark, tightly capped; refrigeration extends solution stability
Questions about Enclomiphene Citrate — Research Liquid
How is enclomiphene different from clomiphene?
Clomiphene citrate is a mixture of two geometric isomers. Enclomiphene is the trans-isomer alone — the antagonist-leaning, faster-clearing component. The cis-isomer, zuclomiphene, is estrogenic and long-lived, and separating the two was the reason enclomiphene was developed as a distinct entity.
Is enclomiphene a peptide?
No. It is a non-peptide small molecule of the triphenylethylene class, chemically related to tamoxifen. It acts on estrogen receptors, whereas the peptides it is often compared with, such as gonadorelin or hCG, act at their own receptors within the same hormonal axis.
What documentation is provided?
Each lot is HPLC tested for purity and identity, with a lot-matched certificate of analysis available on request. Keeping that document with your study records maintains traceability between the characterised material and the data produced from it.
Can this be used by people?
No. This is a research chemical for laboratory use only. It is not a medicine, is not dispensed under prescription, and is not intended for human or veterinary administration. No dosing, cycling or protocol guidance is provided with it.
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