- ≥98% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Metabolic & Circadian Compounds
Cardarine (GW-501516)
Non-peptide PPARδ agonist research chemical, capsules or 20 mg/mL liquid
- FormOral capsules in a sealed bottle, or 30 mL solution in an amber dropper bottle
- Mol. weight453.50 g/mol
- Research areasFatty-acid oxidation and PDK4/CPT1 expression, muscle fibre-type gene programmes, lipid and lipoprotein handling, anti-doping detection chemistry
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
GW-501516, widely catalogued as Cardarine and sometimes as GW1516 or endurobol, is a synthetic small molecule that acts as a high-affinity agonist at peroxisome proliferator-activated receptor delta (PPARδ, also written PPARβ/δ). It is not a peptide and not a SARM: structurally it is a thiazole-containing phenoxyacetic acid bearing a trifluoromethylphenyl group, with a molecular weight of roughly 453.5 g/mol.
Specifications
Identity
- CAS number
- 317318-70-0
- Molecular formula
- C21H18F3NO3S2
- Molecular weight
- 453.50 g/mol
Supply & purity
- Form
- Oral capsules in a sealed bottle, or 30 mL solution in an amber dropper bottle
- Purity
- ≥98% by HPLC; lot-matched COA available
- Available sizes
- 10 mg × 60 capsules; 30 mL liquid at 20 mg/mL
- Solubility
- Poorly water soluble; typically dissolved in DMSO or ethanol for in-vitro work
Additional detail
- Compound class
- Non-steroidal PPARδ (PPARβ/δ) agonist; nuclear receptor ligand
- Also known as
- Cardarine, GW1516, GSK-516, endurobol
- Chemical description
- Phenoxyacetic acid linked through a thioether to a 4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole
- Molecular target
- PPARδ; acts with RXR as a heterodimeric transcription factor
- Research areas
- Fatty-acid oxidation and PDK4/CPT1 expression, muscle fibre-type gene programmes, lipid and lipoprotein handling, anti-doping detection chemistry
- Regulatory status
- Not an approved drug; not a dietary supplement or dietary ingredient; WADA prohibited (S4 metabolic modulators)
- Storage
- Room temperature in the sealed container, dry and protected from light; refrigerate stock solutions
Questions about Cardarine (GW-501516)
Is Cardarine a SARM?
No. Despite being sold alongside them, GW-501516 does not touch the androgen receptor. It is a PPARδ agonist — a nuclear receptor ligand that alters gene transcription in metabolic pathways. Grouping it with SARMs is a marketing convention, not a pharmacological one.
What purity and documentation are supplied?
Each lot is analysed by HPLC to at least 98% purity with identity confirmation, and a lot-matched certificate of analysis is available on request. Independent testing of consumer products in this category has often found mislabelled content, which is exactly why lot-level documentation matters.
How is it prepared for in-vitro work?
GW-501516 is poorly soluble in water. Cell-based studies generally prepare a concentrated stock in DMSO or ethanol and dilute into culture medium, keeping the final vehicle concentration low and matched in control wells. Stock solutions are usually stored cold and protected from light.
Is it detectable in anti-doping testing?
Yes. It is listed by WADA as a prohibited metabolic modulator, and validated LC-MS/MS assays detect both the parent compound and its sulfoxide and sulfone metabolites. Much of the analytical literature on this molecule exists for that purpose.
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