- HPLC tested for purity and identity; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Metabolic & Circadian Compounds
SR9009 (Stenabolic)
Synthetic Rev-Erb nuclear receptor agonist studied in circadian and metabolic models
- Mol. weight437.94 g/mol
- Research areasCircadian gene expression, mitochondrial biogenesis, lipid and glucose handling, macrophage inflammatory signalling
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
SR9009, widely known by the research label Stenabolic, is not a peptide. It is a synthetic small molecule developed as an agonist of the Rev-Erb nuclear receptors, REV-ERBα (NR1D1) and REV-ERBβ (NR1D2). These heme-binding receptors act as transcriptional repressors within the core circadian clock, linking the timing machinery of the cell to genes governing lipid and glucose metabolism, mitochondrial biogenesis and inflammatory signalling.
Its research profile stems from a set of rodent studies in which Rev-Erb agonism altered metabolic parameters and mitochondrial gene expression, producing the popular but imprecise description of an exercise mimetic. The published pharmacology carries important caveats: SR9009 shows poor oral bioavailability in reported mouse pharmacokinetics, and later work has argued that some of its cellular effects occur independently of Rev-Erb receptors, meaning target attribution cannot be assumed from phenotype alone.
SR9009 is not an approved drug in any jurisdiction, is not a dietary supplement, and is prohibited in sport by the World Anti-Doping Agency under the hormone and metabolic modulator category. MyPeptide supplies it as 10 mg capsules in bottles of 60 and as a 30 mL liquid at 20 mg/mL, HPLC tested with a lot-matched certificate of analysis. Sold for laboratory research use only.
Specifications
Identity
- CAS number
- 1379686-30-2
- Molecular formula
- C20H24ClN3O4S
- Molecular weight
- 437.94 g/mol
Supply & purity
- Purity
- HPLC tested for purity and identity; lot-matched COA available
Additional detail
- Compound class
- Synthetic small molecule; nuclear receptor (Rev-Erb) agonist — not a peptide
- Molecular targets
- REV-ERBα (NR1D1) and REV-ERBβ (NR1D2)
- Also known as
- Stenabolic, SR-9009
- Available formats
- 10 mg × 60 capsules; 30 mL solution at 20 mg/mL
- Mechanistic role
- Enhances Rev-Erb transcriptional repression within the core circadian feedback loop
- Research areas
- Circadian gene expression, mitochondrial biogenesis, lipid and glucose handling, macrophage inflammatory signalling
- Reported pharmacokinetics
- Low oral bioavailability and short half-life reported in mouse studies
- Regulatory status
- Not approved as a medicine; not a dietary supplement; WADA-prohibited in sport
- Storage
- Cool, dry, dark; solution refrigerated and tightly capped
Questions about SR9009 (Stenabolic)
Is SR9009 a peptide or a SARM?
Neither. SR9009 is a synthetic small molecule that acts on the Rev-Erb nuclear receptors, which are circadian clock components. SARMs target the androgen receptor, and peptides are amino acid chains. SR9009 belongs to the metabolic modulator category rather than either of those.
What is the concern about off-target activity?
Published work found that SR9009 retained cellular activity in cells lacking both Rev-Erb receptors, which means at least some of its effects are not mediated by its nominal target. Experiments should include genetic controls rather than assuming that any observed change reflects Rev-Erb engagement.
What is its legal and regulatory status?
SR9009 is not approved as a medicine anywhere, is not a lawful dietary supplement ingredient, and is on the World Anti-Doping Agency prohibited list under hormone and metabolic modulators. It is offered here only as a research chemical for laboratory use.
Which format should a laboratory choose?
The 20 mg/mL liquid is easier to dilute accurately for in-vitro work, since volumes can be measured directly. The 10 mg capsules suit study designs that require a fixed unit format. The compound itself is identical between the two.
Related
