- Lot-matched certificate of analysis
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Research Compounds (SARMs & Small Molecules)
Tadalafil — Research Liquid
PDE5 inhibitor reference listing — 30 mL at 30 mg/mL, long half-life profile
- FormClear solution in an amber bottle with a graduated dispenser
- Mol. weight389.40 g/mol
Overview
Tadalafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), the enzyme that hydrolyses cyclic guanosine monophosphate in vascular smooth muscle. It is a small heterocyclic molecule — a beta-carboline-derived tetracyclic diketopiperazine, molecular formula C22H19N3O4 and molecular weight about 389.4 g/mol — and is not a peptide. It is best known in the regulatory record as the active ingredient of Cialis and Adcirca.
As a matter of public regulatory fact, tadalafil holds approvals for erectile dysfunction, for the signs and symptoms of benign prostatic hyperplasia, and — under a separate brand and strength — for pulmonary arterial hypertension. Its long plasma half-life relative to other PDE5 inhibitors is the pharmacological property most often discussed in the literature. The 30 mL solution at 30 mg/mL listed here is presented for reference and analytical purposes only.
Specifications
Identity
- CAS number
- 171596-29-5
- Molecular formula
- C22H19N3O4
- Molecular weight
- 389.40 g/mol
Supply & purity
- Form
- Clear solution in an amber bottle with a graduated dispenser
- Solubility
- Practically insoluble in water; soluble in DMSO and in organic solvents used for analytical work
Additional detail
- Listing type
- Prescription-only reference item; released only against valid authorisation
- Listed presentation
- 30 mL at 30 mg/mL
- Compound class
- Selective phosphodiesterase type 5 (PDE5) inhibitor
- Chemical description
- Tetracyclic beta-carboline-derived diketopiperazine with a methylenedioxyphenyl substituent
- Reference brand names
- Cialis (ED and BPH indications); Adcirca (pulmonary arterial hypertension)
- Mechanism
- Blocks cGMP hydrolysis by PDE5, prolonging nitric-oxide-driven smooth muscle relaxation
- Approved indications (regulatory fact)
- Erectile dysfunction; signs and symptoms of benign prostatic hyperplasia; pulmonary arterial hypertension
- Pharmacology note
- Long elimination half-life relative to sildenafil and vardenafil; PDE5-selective with modest PDE11 affinity
- Storage
- Room temperature, upright, tightly closed and protected from light
Units and conversions
Capsule and troche strengths are stated per unit, so the figure a method needs is usually a conversion rather than a dilution. The mcg to mg converter handles the milligram-to-microgram step, and the millilitre arithmetic if you are working from a solution format instead.
Certificate of analysis
Every lot of Tadalafil — Research Liquid is released against its own lot documentation, and where the manufacturer issues a certificate of analysis for it, that certificate is the record for the lot rather than a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
This listing carries no purity percentage, so none is claimed for it here. Where the manufacturer issues analytical documentation for a lot of this item, it is passed on unaltered — ask and we will send whatever exists.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Tadalafil — Research Liquid
Is this available without a prescription?
No. Tadalafil is a prescription-only medicine in the United States and comparable jurisdictions. This listing exists as an institutional reference entry and material is released only against valid authorisation from a licensed practitioner or a credentialed research institution.
What is tadalafil approved for?
As a matter of public regulatory record, it is approved for erectile dysfunction, for the signs and symptoms of benign prostatic hyperplasia, and — under a separate brand and strength — for pulmonary arterial hypertension. Stating those approvals is a factual description, not a recommendation.
Is a certificate of analysis available?
Yes. Identity and purity are documented on a lot-matched certificate of analysis, available on request when you quote the lot number. For reference and analytical work, lot-level documentation is the point of the listing.
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