- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
IGF-1 DES (1-3)
DES(1-3) IGF-1 — 67-residue truncated analogue, low IGFBP affinity
- FormLyophilized powder, sealed glass vial
- Mol. weight7371.30 g/mol
- Research areasIGF-1R signalling, myoblast differentiation, binding-protein-independent assays
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
IGF-1 DES(1-3) is a truncated analogue of insulin-like growth factor 1 in which the first three N-terminal residues — glycine, proline and glutamate — have been removed, leaving a 67-amino-acid chain of roughly 7371 g/mol. Unlike most engineered analogues, DES(1-3) is not purely synthetic in origin: it was first identified as a naturally occurring form isolated from bovine colostrum and human brain tissue, produced by a specific protease acting on native IGF-1.
Deleting the Glu3 residue removes a critical contact point for the IGF binding proteins, and the resulting analogue has been reported to bind IGFBPs with dramatically lower affinity than intact IGF-1 while retaining full activity at the IGF-1 receptor. In binding-protein-rich systems such as serum-containing culture media, that translates into substantially greater apparent potency, which is why DES(1-3) became a standard tool for probing IGF-1 receptor signalling without binding-protein interference.
Specifications
Identity
- CAS number
- 112603-35-7
- Molecular weight
- 7371.30 g/mol
- Chain length
- 67 amino acids (native IGF-1 minus the N-terminal Gly-Pro-Glu)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 0.1 mg, 1 mg
Handling & storage
- Storage (lyophilized)
- −20 °C or below, sealed and protected from light and moisture
Additional detail
- Also known as
- DES(1-3) IGF-1, IGF-1 DES, des-Gly-Pro-Glu IGF-1
- Key modification
- Deletion of residues 1–3, removing the Glu3 IGFBP contact
- Protein class
- Truncated insulin-like growth factor analogue
- Primary target
- IGF-1 receptor (IGF-1R), a receptor tyrosine kinase
- Origin note
- Also occurs naturally; first isolated from bovine colostrum and brain tissue
- Research areas
- IGF-1R signalling, myoblast differentiation, binding-protein-independent assays
Questions about IGF-1 DES (1-3)
What is IGF-1 DES(1-3)?
It is a 67-amino-acid analogue of insulin-like growth factor 1 missing the first three N-terminal residues, Gly-Pro-Glu. That deletion greatly reduces binding to IGF binding proteins while retaining activity at the IGF-1 receptor, making it a useful in vitro research tool.
Why is DES(1-3) more potent in culture?
Its potency advantage is contextual rather than intrinsic. Native IGF-1 is largely captured by binding proteins present in serum and secreted by cells, whereas DES(1-3) escapes that sequestration, so more of what is added actually reaches the receptor.
How does it differ from IGF-1 LR3?
Both evade IGF binding proteins, but LR3 substitutes Arg at position 3 and adds a 13-residue N-terminal extension, while DES(1-3) simply deletes the first three residues. LR3 is larger and generally reported to have the longer functional window.
Does it occur naturally?
Yes. DES(1-3) IGF-1 was first isolated from bovine colostrum and human brain tissue, where it appears to be generated by proteolytic processing of intact IGF-1. That natural origin distinguishes it from purely engineered analogues in the same product class.
Is the purity third-party verified?
Yes. Every lot is analysed by an independent laboratory using HPLC to confirm ≥99% purity and identity, and a lot-matched Certificate of Analysis is available on request. Check the lot number on your vial against the certificate.
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