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Ipamorelin

Selective GHS-R1a pentapeptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2

In stock·3 formats available·CAS 170851-70-4

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FormLyophilized powder, sealed glass vial
Mol. weight711.85 g/mol
Research areasGHS-R1a signalling, secretagogue selectivity, gastrointestinal motility models

Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.

Overview

Ipamorelin is a synthetic pentapeptide developed as a selective agonist of the growth hormone secretagogue receptor, GHS-R1a — the same receptor targeted by the endogenous hormone ghrelin. Its sequence, Aib-His-D-2-Nal-D-Phe-Lys-NH2, packs an unnatural aminoisobutyric acid residue, two D-amino acids and a C-terminal amide into just five residues, giving a compact molecule of about 712 g/mol that resists ordinary proteolysis.

What made ipamorelin notable in the peptide literature is its selectivity. Earlier growth hormone secretagogues such as GHRP-6 and hexarelin were reported to also move cortisol, prolactin and appetite signalling, whereas ipamorelin was characterised as producing a comparatively clean growth hormone response in animal models. That selectivity is why it became a standard tool compound for isolating GHS-R1a signalling from the broader neuroendocrine background.

Specifications

Identity

CAS number: 170851-70-4
Molecular formula: C38H49N9O5
Molecular weight: 711.85 g/mol
Amino acid sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
Chain length: 5 residues, C-terminal amide
Peptide class: Growth hormone releasing peptide (GHRP), GHS-R1a agonist

Supply & purity

Form: Lyophilized powder, sealed glass vial
Purity: ≥99% by HPLC; lot-matched COA available
Available sizes: 2 mg, 5 mg, 10 mg

Handling & storage

Storage (lyophilized): −20 °C, sealed and protected from light and moisture

Additional detail

Unnatural residues: Aib (2-aminoisobutyric acid), D-2-naphthylalanine, D-phenylalanine
Primary target: Growth hormone secretagogue receptor 1a (ghrelin receptor)
Research areas: GHS-R1a signalling, secretagogue selectivity, gastrointestinal motility models

Questions about Ipamorelin

What is Ipamorelin?

Ipamorelin is a synthetic pentapeptide agonist of the growth hormone secretagogue receptor GHS-R1a, the receptor for endogenous ghrelin. Laboratories use it as a selective reference compound when studying secretagogue signalling separately from the GHRH pathway.

Why is Ipamorelin called selective?

In comparative animal studies it produced growth hormone release without the parallel cortisol, ACTH and prolactin changes reported for GHRP-6 and hexarelin. That narrower profile lets researchers attribute observed effects to GHS-R1a activation rather than to broader neuroendocrine stimulation.

How does it differ from a GHRH analogue?

Ipamorelin acts at the ghrelin receptor GHS-R1a, a Gq-coupled receptor driving calcium signalling, while sermorelin and CJC-1295 act at the Gs-coupled GHRH receptor and raise cyclic AMP. The two pathways are distinct, which is why combination studies are common in vitro.

Is the purity independently verified?

Yes. Each lot is third-party analysed by HPLC to confirm ≥99% purity and identity, and a lot-matched Certificate of Analysis is available on request. Check the vial's lot number against the certificate when logging the material into your inventory.