- ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
Ipamorelin
Selective GHS-R1a pentapeptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2
- FormLyophilized powder, sealed glass vial
- Mol. weight711.85 g/mol
- Research areasGHS-R1a signalling, secretagogue selectivity, gastrointestinal motility models
Overview
Ipamorelin is a synthetic pentapeptide developed as a selective agonist of the growth hormone secretagogue receptor, GHS-R1a — the same receptor targeted by the endogenous hormone ghrelin. Its sequence, Aib-His-D-2-Nal-D-Phe-Lys-NH2, packs an unnatural aminoisobutyric acid residue, two D-amino acids and a C-terminal amide into just five residues, giving a compact molecule of about 712 g/mol that resists ordinary proteolysis.
What made ipamorelin notable in the peptide literature is its selectivity. Earlier growth hormone secretagogues such as GHRP-6 and hexarelin were reported to also move cortisol, prolactin and appetite signalling, whereas ipamorelin was characterised as producing a comparatively clean growth hormone response in animal models. That selectivity is why it became a standard tool compound for isolating GHS-R1a signalling from the broader neuroendocrine background.
Specifications
Identity
- CAS number
- 170851-70-4
- Molecular formula
- C38H49N9O5
- Molecular weight
- 711.85 g/mol
- Amino acid sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Chain length
- 5 residues, C-terminal amide
- Peptide class
- Growth hormone releasing peptide (GHRP), GHS-R1a agonist
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg, 10 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
Additional detail
- Unnatural residues
- Aib (2-aminoisobutyric acid), D-2-naphthylalanine, D-phenylalanine
- Primary target
- Growth hormone secretagogue receptor 1a (ghrelin receptor)
- Research areas
- GHS-R1a signalling, secretagogue selectivity, gastrointestinal motility models
Working out the concentration
A lyophilized vial carries a mass on the label and no concentration anywhere, so the first calculation of any protocol is the reconstitution one. The peptide concentration calculator converts vial mass plus diluent volume into mg/mL, and back into the draw volume for a given mass.
Certificate of analysis
Every lot of Ipamorelin is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Ipamorelin
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide agonist of the growth hormone secretagogue receptor GHS-R1a, the receptor for endogenous ghrelin. Laboratories use it as a selective reference compound when studying secretagogue signalling separately from the GHRH pathway.
Why is Ipamorelin called selective?
In comparative animal studies it produced growth hormone release without the parallel cortisol, ACTH and prolactin changes reported for GHRP-6 and hexarelin. That narrower profile lets researchers attribute observed effects to GHS-R1a activation rather than to broader neuroendocrine stimulation.
How does it differ from a GHRH analogue?
Ipamorelin acts at the ghrelin receptor GHS-R1a, a Gq-coupled receptor driving calcium signalling, while sermorelin and CJC-1295 act at the Gs-coupled GHRH receptor and raise cyclic AMP. The two pathways are distinct, which is why combination studies are common in vitro.
Is the purity independently verified?
Yes. Each lot is third-party analysed by HPLC to confirm ≥99% purity and identity, and a lot-matched Certificate of Analysis is available on request. Check the vial's lot number against the certificate when logging the material into your inventory.
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