- ≥98% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Ibutamoren (MK-677) Capsules
Orally active non-peptide ghrelin receptor agonist in 30-capsule bottles
- FormOral capsules in a sealed bottle with desiccant
- Mol. weight528.66 g/mol
- Research areasGH and IGF-1 axis, sleep architecture, body composition, bone mineral density, appetite regulation
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Ibutamoren, developed as MK-677 and also designated L-163,191, is not a peptide at all. It is a spiropiperidine small molecule engineered at Merck to reproduce the action of the growth hormone-releasing peptides at the growth hormone secretagogue receptor while surviving the gut. That distinction matters: every other compound in this department is a peptide that would be degraded by digestion, whereas MK-677 was designed from the outset for oral bioavailability, and it is the reason this product ships as capsules rather than a lyophilized vial.
Specifications
Identity
- CAS number
- 159752-10-0
- Molecular formula
- C27H36N4O5S
- Molecular weight
- 528.66 g/mol
Supply & purity
- Form
- Oral capsules in a sealed bottle with desiccant
- Purity
- ≥98% by HPLC; lot-matched COA available
- Available sizes
- 12.5 mg × 30 capsules, 25 mg × 30 capsules
Additional detail
- Compound class
- Non-peptide spiropiperidine growth hormone secretagogue
- Molecular target
- Growth hormone secretagogue receptor 1a (ghrelin receptor)
- Also known as
- MK-677, MK-0677, L-163,191, ibutamoren mesylate (salt form)
- Reported half-life
- Approximately 24 hours in published pharmacokinetic studies
- Research areas
- GH and IGF-1 axis, sleep architecture, body composition, bone mineral density, appetite regulation
- Storage
- Room temperature in the sealed bottle, protected from light, heat and humidity
- Reconstitution
- None required — supplied in finished capsule form
Questions about Ibutamoren (MK-677) Capsules
Is MK-677 actually a peptide?
No. Ibutamoren is a non-peptide spiropiperidine small molecule designed to mimic peptide secretagogues at the ghrelin receptor. Because it lacks a peptide backbone it survives digestion, which is why it is supplied as capsules rather than as a lyophilized powder for reconstitution.
Is the product third-party tested and is a COA available?
Yes. Each lot is analysed by an independent laboratory for purity by HPLC and identity by mass spectrometry, and capsule content is verified against label strength. The certificate of analysis is matched to the lot number on your bottle and available on request.
How should MK-677 capsules be stored?
Keep the bottle sealed at room temperature with the desiccant in place, protected from light, heat and humidity. Unlike lyophilized peptides, no refrigeration or freezing is needed. Avoid bathroom-style humid storage, which softens capsule shells and can cause them to adhere.
Can these capsules be taken by people?
No. MK-677 is supplied strictly for laboratory research by qualified personnel. It is not an approved drug in any jurisdiction, is not a dietary supplement, and must not be consumed by humans or administered to animals outside a properly authorised research setting. We provide no dosing guidance.
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