- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
IGF-1 LR3
Long R3 IGF-1 — 83-residue recombinant analogue, low IGFBP affinity
- FormLyophilized powder, sealed glass vial
- Mol. weight9117.60 g/mol
- Research areasIGF-1R signalling, myoblast and cell proliferation assays, serum-free culture
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
IGF-1 LR3, or Long R3 insulin-like growth factor 1, is an 83-residue recombinant analogue of human IGF-1. Two engineered changes define it: arginine replaces glutamate at position 3, and a 13-amino-acid extension is added to the N-terminus. Together these raise the molecular weight to roughly 9118 g/mol and, more importantly, sharply reduce affinity for the IGF binding proteins that normally sequester more than 95% of circulating IGF-1.
Specifications
Identity
- CAS number
- 946870-92-4
- Molecular formula
- C400H625N111O115S9
- Molecular weight
- 9117.60 g/mol
- Chain length
- 83 amino acids (70-residue IGF-1 core plus 13-residue N-terminal extension)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 0.1 mg, 1 mg
Handling & storage
- Storage (lyophilized)
- −20 °C or below, sealed and protected from light and moisture
Additional detail
- Also known as
- Long R3 IGF-1, LR3 IGF-1
- Key modifications
- Arg substituted for Glu at position 3; N-terminal 13-residue extension
- Protein class
- Recombinant insulin-like growth factor analogue
- Primary target
- IGF-1 receptor (IGF-1R), a receptor tyrosine kinase
- Research areas
- IGF-1R signalling, myoblast and cell proliferation assays, serum-free culture
Questions about IGF-1 LR3
What is IGF-1 LR3?
IGF-1 LR3 is an 83-amino-acid recombinant analogue of insulin-like growth factor 1, carrying an Arg3 substitution and a 13-residue N-terminal extension. Both changes reduce IGF binding protein affinity, making it a dependable IGF-1 receptor agonist in cell culture.
How does it compare with IGF-1 DES(1-3)?
Both evade IGF binding proteins, but by different routes. DES(1-3) removes the first three N-terminal residues, while LR3 substitutes Arg at position 3 and adds an extension. LR3 is larger and generally reported to have the longer working stability.
Is a Certificate of Analysis provided?
Yes. Each lot is third-party tested by HPLC for ≥99% purity and identity, with a lot-matched Certificate of Analysis available on request. Verify the lot number on your vial against the certificate before entering the material into your laboratory records.
Why is a carrier protein recommended?
At the low concentrations typical of cell culture, proteins adsorb onto plastic tubes and pipette tips, silently lowering the delivered amount. Adding a carrier such as 0.1% BSA to dilute working stocks occupies those surfaces and preserves the concentration you intend to apply.
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