- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
CJC-1295 (No DAC / Mod GRF 1-29)
Modified GRF 1-29 tetrasubstituted GHRH fragment, no DAC
- FormLyophilized powder, sealed glass vial
- Mol. weight3367.93 g/mol
- Research areasSomatotropic axis signalling, peptide stability, secretagogue comparison
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
CJC-1295 without DAC, more precisely called Modified GRF 1-29, is a synthetic 29-amino-acid analogue of growth hormone-releasing hormone. It keeps the receptor-binding 1–29 core of GHRH but replaces four residues — positions 2, 8, 15 and 27 — with substitutions chosen to blunt the molecule's main degradation routes: dipeptidyl peptidase-4 cleavage at the N-terminus, asparagine deamidation and methionine oxidation.
The "no DAC" designation distinguishes it from the drug-affinity-complex version. Without the maleimide linker that tethers the peptide to serum albumin, this variant is cleared far faster, which is precisely why laboratories choose it: short exposure windows let researchers study pulsatile GHRH receptor signalling rather than continuous receptor occupancy. It is a common comparator in structure–activity work against native GRF 1-29 and sermorelin.
Specifications
Identity
- CAS number
- 863288-34-0
- Molecular formula
- C152H252N44O42
- Molecular weight
- 3367.93 g/mol
- Amino acid sequence
- Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
- Peptide class
- GHRH analogue (GHRH-R agonist), 29 residues, C-terminal amide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg, 10 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Also known as
- Modified GRF 1-29, Mod GRF (1-29), CJC-1295 without DAC
- Key modifications
- D-Ala2, Gln8, Ala15, Leu27 substitutions on the GRF 1-29 backbone
- Research areas
- Somatotropic axis signalling, peptide stability, secretagogue comparison
Questions about CJC-1295 (No DAC / Mod GRF 1-29)
What is CJC-1295 without DAC?
It is a synthetic 29-amino-acid GHRH analogue, also called Modified GRF 1-29, carrying four substitutions that reduce enzymatic degradation. Without the drug affinity complex it clears quickly, so laboratories use it to study short, pulse-like GHRH receptor activation.
How is it different from CJC-1295 with DAC?
The DAC version adds a maleimidopropionyl linker at Lys30 that binds covalently to serum albumin, extending circulation from minutes to days in animal models. The no-DAC form lacks that linker entirely, giving researchers a short exposure window instead of sustained receptor occupancy.
Why is it also called Mod GRF 1-29?
GRF 1-29 is the receptor-binding fragment of growth hormone-releasing factor. "Modified" refers to the four amino acid substitutions at positions 2, 8, 15 and 27. The CJC-1295 name properly belongs to the DAC-conjugated molecule, but the industry uses both labels interchangeably.
Is a COA available for my lot?
Yes. Every lot is third-party analysed by HPLC to verify ≥99% purity and identity, and a lot-matched Certificate of Analysis is available on request. Compare the lot number on your vial with the certificate before entering the material into your records.
What sizes can I order?
This peptide is stocked in 2 mg, 5 mg and 10 mg lyophilized vials. The 2 mg vial suits short pilot assays and method validation, while 5 mg and 10 mg vials lower the per-milligram cost for longer or multi-arm laboratory studies.
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