- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
CJC-1295 with DAC
Albumin-binding GHRH analogue with drug affinity complex
- FormLyophilized powder, sealed glass vial
- Mol. weight3647.28 g/mol
- Research areasSustained secretagogue signalling, receptor desensitisation, IGF-1 dynamics
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
CJC-1295 with DAC is a synthetic growth hormone-releasing hormone analogue built on the Modified GRF 1-29 backbone and extended with a lysine at position 30 that carries a maleimidopropionyl group — the drug affinity complex, or DAC. That maleimide reacts with the free cysteine-34 thiol of circulating serum albumin, forming a covalent conjugate that shields the peptide from renal clearance and peptidase attack.
The chemistry is the whole point of the molecule. Where unconjugated GHRH fragments disappear within minutes, the albumin-bound form has been reported to persist for days in animal models, producing sustained rather than pulsatile receptor exposure. Researchers therefore use it as a long-acting comparator when they want to isolate what continuous GHRH receptor occupancy does to somatotroph signalling, receptor desensitisation and downstream IGF-1 levels.
Specifications
Identity
- CAS number
- 863288-34-0
- Molecular formula
- C165H269N47O46
- Molecular weight
- 3647.28 g/mol
- Peptide class
- Long-acting GHRH analogue (GHRH-R agonist)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg, 10 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Also known as
- CJC-1295 DAC, DAC:GRF, drug affinity complex GHRH analogue
- Structure
- Modified GRF 1-29 (D-Ala2, Gln8, Ala15, Leu27) extended with Lys30-maleimidopropionamide
- Conjugation chemistry
- Maleimide–thiol addition to cysteine-34 of serum albumin
- Research areas
- Sustained secretagogue signalling, receptor desensitisation, IGF-1 dynamics
Questions about CJC-1295 with DAC
What does DAC mean in CJC-1295 with DAC?
DAC stands for drug affinity complex. It refers to the maleimidopropionyl group attached to the C-terminal lysine, which reacts with cysteine-34 on serum albumin. The resulting covalent conjugate protects the peptide from clearance and greatly extends its residence time in animal models.
Which buffers should be avoided during reconstitution?
Avoid any solvent containing free thiols or reducing agents such as DTT, TCEP or beta-mercaptoethanol. These react with the maleimide group and destroy the albumin-binding chemistry. Bacteriostatic or sterile water is the standard choice for laboratory reconstitution.
Is a Certificate of Analysis available?
Yes. Every lot is third-party tested by HPLC for ≥99% purity and identity, with a lot-matched Certificate of Analysis available on request. Verify that the lot number on your vial matches the certificate before recording the material in your laboratory inventory.
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