- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Hexarelin
2-methyl-Trp hexapeptide GHS-R1a agonist with CD36 activity
- FormLyophilized powder, sealed glass vial
- Mol. weight887.04 g/mol
- Research areasSecretagogue pharmacology, cardiac signalling, receptor desensitisation
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Hexarelin is a synthetic hexapeptide growth hormone secretagogue built on the GHRP-6 scaffold, differing by a single methyl group: the D-tryptophan at position 2 is replaced with 2-methyl-D-tryptophan. That small change has been reported to increase metabolic stability and potency at the growth hormone secretagogue receptor GHS-R1a, and it defines the compound's sequence, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2.
What separates hexarelin from the rest of the GHRP family in the research literature is its second target. Cardiovascular studies identified binding to CD36, a scavenger receptor expressed in heart tissue, and a body of work has examined hexarelin's cardiac effects in models where growth hormone release itself does not explain the observations. It is therefore used both as a secretagogue reference compound and as a probe for GHS-R1a-independent signalling.
Specifications
Identity
- CAS number
- 140703-51-1
- Molecular formula
- C47H58N12O6
- Molecular weight
- 887.04 g/mol
- Amino acid sequence
- His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
- Chain length
- 6 residues, C-terminal amide
- Peptide class
- Growth hormone releasing peptide (GHRP), GHS-R1a agonist
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
Additional detail
- Also known as
- Examorelin, EP-23905
- Secondary target
- CD36 scavenger receptor, studied in cardiac tissue models
- Research areas
- Secretagogue pharmacology, cardiac signalling, receptor desensitisation
Questions about Hexarelin
What is Hexarelin?
Hexarelin is a synthetic hexapeptide agonist of the growth hormone secretagogue receptor GHS-R1a, structurally a methylated analogue of GHRP-6. Laboratories use it as a potent reference secretagogue and as a probe for CD36-mediated signalling in cardiac tissue.
How does Hexarelin differ from GHRP-6?
The only structural difference is a methyl group on the position-2 D-tryptophan. That single modification has been reported to improve metabolic stability and potency at GHS-R1a, which is why the two are often studied side by side in structure–activity work.
What is the CD36 connection?
Beyond GHS-R1a, hexarelin binds CD36, a scavenger receptor found in cardiac tissue. Binding studies and isolated-heart preparations have used this interaction to investigate cardiac effects that persist in models where growth hormone release cannot account for the results.
Is the purity independently confirmed?
Yes. Every lot is third-party analysed by HPLC to verify ≥99% purity and identity, and a lot-matched Certificate of Analysis is available on request. Check that the lot number printed on your vial matches the certificate you receive.
What vial sizes are offered?
Hexarelin is stocked in 2 mg and 5 mg lyophilized vials. The 2 mg size suits receptor binding assays and pilot experiments, while the 5 mg vial is more economical for extended comparative studies across the growth hormone secretagogue family.
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