- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Sermorelin
Synthetic GHRH (1–29) amide research peptide, 29 amino acids
- FormLyophilized powder, sealed glass vial
- Mol. weight3357.93 g/mol
- Research areasSomatotropic axis signalling, endocrine receptor pharmacology, ageing models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Sermorelin is a synthetic 29-amino-acid peptide that reproduces the biologically active N-terminal fragment of human growth hormone-releasing hormone, GHRH (1–29) amide. The full endogenous hormone is 44 residues long, but decades of endocrine work established that the first 29 carry essentially all of the receptor-binding information, which is why this truncated analogue became a standard laboratory tool for probing the GHRH receptor.
Chemically it is a C-terminally amidated linear peptide with a molecular weight near 3358 g/mol, produced by solid-phase synthesis and purified by reversed-phase HPLC. Because it acts at the pituitary GHRH receptor rather than at the ghrelin receptor, researchers use it to study the hypothalamic arm of the somatotropic axis — receptor occupancy, cyclic AMP signalling, and the pulsatile pattern of growth hormone release seen in intact animal models.
Specifications
Identity
- CAS number
- 86168-78-7
- Molecular formula
- C149H246N44O42S
- Molecular weight
- 3357.93 g/mol
- Amino acid sequence
- Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
- Chain length
- 29 amino acids, C-terminal amide
- Peptide class
- GHRH analogue (growth hormone secretagogue, GHRH-R agonist)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 2 mg, 5 mg, 10 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Primary target
- GHRH receptor (GHRH-R), a class B GPCR on pituitary somatotrophs
- Research areas
- Somatotropic axis signalling, endocrine receptor pharmacology, ageing models
Questions about Sermorelin
What is Sermorelin?
Sermorelin is a synthetic 29-amino-acid peptide identical to the N-terminal active fragment of human growth hormone-releasing hormone, GHRH (1–29) amide. It is used in laboratory settings as a reference GHRH receptor agonist for endocrine signalling and secretagogue research.
Is your Sermorelin third-party tested?
Yes. Every lot is analysed by reversed-phase HPLC to confirm ≥99% purity and identity, and a lot-matched Certificate of Analysis is available on request. Match the lot number printed on your vial to the COA so your records reference the exact material tested.
How should the vial be stored?
Store the lyophilized powder at −20 °C away from light and moisture, where it is stable long term. Once reconstituted, keep the solution refrigerated at 2–8 °C and use it within your validated study window, avoiding repeated freeze–thaw cycles.
How does Sermorelin differ from Ipamorelin?
They act at different receptors. Sermorelin is a GHRH analogue that binds the GHRH receptor, while ipamorelin is a pentapeptide agonist of the ghrelin receptor GHS-R1a. Researchers sometimes study them together to examine whether the two pathways interact in cell-based models.
What does the amide at the C-terminus mean?
The C-terminal residue is supplied as an amide rather than a free carboxylic acid. This mirrors the natural processing of GHRH, removes a negative charge at the chain end and is generally associated with improved receptor recognition and resistance to carboxypeptidase activity.
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