- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Tesamorelin
Trans-3-hexenoyl GHRH (1–44) analogue research peptide
- FormLyophilized powder, sealed glass vial
- Mol. weight5135.86 g/mol
- Research areasSomatotropic axis signalling, visceral adipose metabolism, peptide stability
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Tesamorelin is a synthetic analogue of human growth hormone-releasing hormone in which the full 44-residue GHRH sequence carries a trans-3-hexenoyl group attached to the N-terminal tyrosine. That single lipophilic modification is the point of the molecule: the unprotected N-terminus of native GHRH is rapidly clipped by dipeptidyl peptidase-4, and acylation at this position is studied for how it slows that degradation while preserving receptor recognition.
With a molecular weight of roughly 5136 g/mol it is one of the larger GHRH-family peptides offered for laboratory work, and considerably longer than truncated fragments such as sermorelin or modified GRF 1-29. It is produced by solid-phase synthesis, purified by reversed-phase HPLC and supplied as a lyophilized powder. In research settings it is used as a stable, well-characterised GHRH receptor agonist for endocrine signalling studies and for comparative work on adipose tissue metabolism in animal models.
Specifications
Identity
- CAS number
- 218949-48-5
- Molecular formula
- C221H366N72O67S
- Molecular weight
- 5135.86 g/mol
- Amino acid sequence
- trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
- Chain length
- 44 amino acids, N-terminally acylated, C-terminal amide
- Peptide class
- GHRH analogue (GHRH-R agonist)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg, 20 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Key modification
- trans-3-hexenoyl group on the N-terminal tyrosine
- Research areas
- Somatotropic axis signalling, visceral adipose metabolism, peptide stability
Questions about Tesamorelin
What is Tesamorelin?
Tesamorelin is a synthetic analogue of the full 44-amino-acid growth hormone-releasing hormone sequence, modified with a trans-3-hexenoyl group at the N-terminus. Laboratories use it as a stabilised GHRH receptor agonist in endocrine signalling and metabolic research models.
How does Tesamorelin differ from Sermorelin?
Sermorelin is the unmodified 1–29 fragment of GHRH, whereas tesamorelin is the full 1–44 sequence carrying an N-terminal acyl group. Researchers compare the two to study how chain length and N-terminal protection affect enzymatic stability and receptor activation in vitro.
Is a Certificate of Analysis provided?
Yes. Each lot is third-party tested by HPLC for ≥99% purity and identity, and a lot-matched COA is available on request. Cross-check the lot number on the vial label against the certificate so your laboratory records refer to the exact batch you received.
How stable is the reconstituted peptide?
Once dissolved, tesamorelin is far less stable than the dry powder. Keep the solution at 2–8 °C, shielded from light, and use it within the window your laboratory has validated. Aliquoting before storage avoids the degradation caused by repeated freeze–thaw cycles.
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