- ≥99% by HPLC on the semaglutide input; lot-matched COA
- Lot-matched certificate of analysis
- Ships next business day, tracked
Semaglutide + Vitamin B12
Co-formulated semaglutide with methylcobalamin in a single research vial
- Research areasGLP-1 receptor pharmacology, appetite and glucose-handling models, one-carbon metabolism, methylation research
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
This vial pairs semaglutide, the acylated 31-residue GLP-1 receptor agonist analog, with methylcobalamin, the methylated coenzyme form of vitamin B12. The combination exists because metabolic study designs that use an incretin agonist frequently want a B12 arm in the same preparation: reduced food intake in a model narrows micronutrient supply, and cobalamin status is a recognised variable in one-carbon and methylation biochemistry.
Semaglutide contributes the pharmacology. Its Aib substitution at position 2 blocks DPP-4 cleavage, and a gamma-Glu-(AEEA)₂-C18 diacid chain at Lys26 drives strong albumin binding, giving the long circulating half-life that made weekly dosing feasible in the approved medicines built on the same molecule. Methylcobalamin contributes chemistry rather than receptor activity: it is the cofactor for methionine synthase and carries the corrin-bound cobalt that gives the solution its characteristic pink-red tint.
Specifications
Supply & purity
- Purity
- ≥99% by HPLC on the semaglutide input; lot-matched COA
- Available sizes
- 5 mg semaglutide + B12; 10 mg semaglutide + B12
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, shielded from light; use within the study window
Additional detail
- Product type
- Two-component research blend, single lyophilized vial
- Components
- Semaglutide and methylcobalamin (vitamin B12)
- Semaglutide CAS number
- 910463-68-2
- Semaglutide formula
- C187H291N45O59
- Semaglutide molecular weight
- 4113.58 g/mol
- Semaglutide class
- Acylated GLP-1 receptor agonist analog (incretin mimetic), 31-residue backbone
- Methylcobalamin CAS number
- 13422-55-4
- Methylcobalamin formula
- C63H91CoN13O14P
- Methylcobalamin molecular weight
- 1344.38 g/mol
- Appearance
- Pale pink to red lyophilized cake; pink-red solution once reconstituted
- Research areas
- GLP-1 receptor pharmacology, appetite and glucose-handling models, one-carbon metabolism, methylation research
Questions about Semaglutide + Vitamin B12
How much of each component is in a vial?
The label states semaglutide content — 5 mg or 10 mg — with methylcobalamin co-formulated alongside it. The exact cobalamin loading for your lot appears on the lot-matched certificate of analysis, which is the authoritative figure for both components.
Why is the solution pink or red?
That is the cobalamin. The corrin ring holds a cobalt ion whose electronic structure absorbs strongly in the visible range, so B12 solutions are deep pink to red. It doubles as an integrity cue: noticeable fading means the vial has taken more light exposure than it should.
Is the blend third-party tested?
Yes. The semaglutide input is released against a ≥99% HPLC purity specification with mass-spectrometric identity confirmation, and each finished vial carries a lot number tied to that certificate of analysis. Request the current lot COA before ordering if you need to review it first.
Should I choose the blend or separate vials?
The blend suits designs that hold both components at a fixed ratio, since it removes a reconstitution step and a dilution calculation. If your protocol needs the semaglutide-to-cobalamin relationship to vary, or a semaglutide-only control arm, separate vials are the better article.
How does storage differ from plain semaglutide?
Temperature handling is the same — −20 °C sealed, 2–8 °C once in solution. Light protection is stricter: cobalamin degrades under ambient and UV light far faster than the peptide does, so the vial should be kept boxed, wrapped or in amber whenever it is not in use.
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