- ≥99% by HPLC per component; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Semaglutide + Cagrilintide (CagriSema)
Co-formulated GLP-1 receptor agonist and amylin analog research blend
- FormLyophilized powder, sealed glass vial with flip-off seal
- Research areasIncretin and amylin receptor pharmacology, satiation signaling, energy balance models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
This vial pairs two long-acting metabolic peptides in a single lyophilized cake: semaglutide, an acylated 31-residue GLP-1 receptor agonist analog, and cagrilintide, a non-fibrillating amylin analog that signals through calcitonin and amylin receptor complexes. The combination is widely referred to in the literature by the shorthand CagriSema, and both components are supplied here at a 1:1 mass ratio.
The pairing exists because incretin and amylin signaling are only partly overlapping. GLP-1 receptor agonism has been studied for its effects on insulin secretion, gastric emptying and hypothalamic appetite circuits, while amylin receptor agonism engages the area postrema and hindbrain satiation pathways through a separate receptor family. Researchers combine them to ask whether the two inputs act additively on energy-balance endpoints, whether one arm shifts body composition differently, and how receptor crosstalk behaves over longer exposures.
Specifications
Supply & purity
- Form
- Lyophilized powder, sealed glass vial with flip-off seal
- Purity
- ≥99% by HPLC per component; lot-matched COA available
- Available sizes
- 5 mg total (2.5 mg / 2.5 mg), 10 mg total (5 mg / 5 mg)
- Solubility
- Bacteriostatic water; dilute buffers where assay pH matters
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Product type
- Two-peptide metabolic research blend, co-lyophilized in one vial
- Components
- Semaglutide and cagrilintide (AM833), 1:1 by mass
- Semaglutide
- CAS 910463-68-2 · C187H291N45O59 · 4113.58 g/mol
- Cagrilintide
- CAS 1415456-99-3 · C194H309N55O59S2 · 4409.07 g/mol
- Semaglutide class
- Acylated GLP-1 receptor agonist analog, 31 residues, Aib at position 2
- Cagrilintide class
- Long-acting amylin analog acting at calcitonin and AMY1-AMY3 receptor complexes
- Research areas
- Incretin and amylin receptor pharmacology, satiation signaling, energy balance models
Questions about Semaglutide + Cagrilintide (CagriSema)
What is the ratio of the two peptides?
Both sizes are supplied at a 1:1 mass ratio. The 5 mg vial contains 2.5 mg of semaglutide and 2.5 mg of cagrilintide; the 10 mg vial contains 5 mg of each. Because the two molecular weights differ slightly, the molar ratio is close to but not exactly one to one.
Why is the pair studied together rather than separately?
Incretin and amylin receptors sit in largely separate anatomical circuits, so laboratories investigate whether engaging both produces different energy-balance and body-composition outcomes than either arm alone. Well-designed experiments still include single-agent and vehicle controls alongside the blend.
What purity documentation is provided?
Each component is tested by HPLC to at least 99% purity with identity confirmed by mass spectrometry. A lot-matched certificate of analysis is available and is tied to the vial number shipped, so the analytical data stays traceable to the material in your hands.
How should the vial be stored?
Keep the sealed lyophilized vial at −20 °C, protected from light and moisture. Once reconstituted, store at 2–8 °C and use within your documented study window. Aliquot rather than repeatedly freezing and thawing a single stock solution.
Does co-formulation affect stability?
That is itself a research question. Amylin-family peptides can aggregate, so analytical groups check the blend by HPLC, size-exclusion chromatography and thioflavin-T assays to confirm both components remain intact and monomeric in the shared matrix before biological work begins.
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