- Purity (peptide): ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
Tirzepatide + Vitamin B12
Dual GIP/GLP-1 agonist peptide co-formulated with methylcobalamin in one vial
- FormLyophilized co-formulated powder, sealed glass vial with flip-off seal
- Research areasIncretin receptor signalling, energy balance and glycaemic models, cofactor co-formulation stability
Overview
This blend combines two well-characterised components in a single vial: tirzepatide, a 39-residue acylated dual GIP and GLP-1 receptor agonist, and methylcobalamin, the methylated coenzyme form of vitamin B12. The two are chemically unrelated and act through entirely separate systems. Tirzepatide is a synthetic peptide engineered around a GIP backbone with a C20 fatty diacid chain that confers albumin binding and a long circulating half-life. Methylcobalamin is a deep-red cobalt-corrinoid cofactor for methionine synthase.
Blends of this kind exist in compounding and research practice because the two components address different variables in the same experimental system: the incretin arm drives the metabolic endpoints under study, while B12 is a co-formulated cofactor whose presence is one of the variables researchers may wish to hold constant or manipulate. Co-formulation also affects the formulation science itself — the corrinoid is strongly light-sensitive and colours the solution, which changes how a vial must be handled and how spectrophotometric assays are interpreted.
Specifications
Identity
- Peptide class
- Acylated dual GIP/GLP-1 receptor agonist (twincretin), 39 residues
Supply & purity
- Form
- Lyophilized co-formulated powder, sealed glass vial with flip-off seal
- Available sizes
- 10 mg tirzepatide + B12; 20 mg tirzepatide + B12
Additional detail
- Component 1
- Tirzepatide — dual GIP/GLP-1 receptor agonist peptide
- Component 2
- Methylcobalamin — methylated coenzyme form of vitamin B12
- Purity (peptide)
- ≥99% by HPLC; lot-matched COA available
- CAS number (tirzepatide)
- 2023788-19-2
- Molecular formula (tirzepatide)
- C225H348N48O68
- Molecular weight (tirzepatide)
- 4813.45 g/mol
- CAS number (methylcobalamin)
- 13422-55-4
- Molecular formula (methylcobalamin)
- C63H91CoN13O14P
- Molecular weight (methylcobalamin)
- 1344.38 g/mol
- Research areas
- Incretin receptor signalling, energy balance and glycaemic models, cofactor co-formulation stability
- Storage
- −20 °C lyophilized; 2–8 °C reconstituted, protected from light at all times
Working out the concentration
Reconstitution is where the arithmetic lives. The same vial made up with 1 mL or with 3 mL of diluent gives three-fold different numbers, which is why a reconstitution volume calculator is more use here than a fixed table: enter the vial mass and your diluent volume and read the concentration back.
Certificate of analysis
Every lot of Tirzepatide + Vitamin B12 is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity (peptide): ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Tirzepatide + Vitamin B12
What exactly is in this vial?
Two components: tirzepatide, a 39-residue acylated dual GIP and GLP-1 receptor agonist peptide, and methylcobalamin, the methylated coenzyme form of vitamin B12. They are chemically unrelated and act through separate systems; the blend simply supplies both from one lyophilized preparation.
How does this differ from the plain tirzepatide vial?
The peptide is the same molecule with the same specifications. The difference is the co-formulated methylcobalamin, which colours the reconstituted solution, makes it strongly light-sensitive, and interferes with UV-based peptide quantification unless the components are chromatographically separated.
Why is light protection emphasised so heavily?
Methylcobalamin's cobalt-carbon bond is cleaved by light. Photolysis is fast enough to alter the preparation during ordinary bench work under bright lighting, so amber containers, foil wrapping and short exposure times are standard practice for any corrinoid-containing solution.
What purity documentation is provided?
The peptide component is third-party HPLC tested to at least 99% purity, with a lot-matched certificate of analysis available on request covering identity and purity. Keep the COA with your study record so material and data remain traceable to one another.
Which sizes are available?
Two: 10 mg of tirzepatide with B12, and 20 mg of tirzepatide with B12. The stated milligram figure refers to the peptide content; the cofactor is co-formulated at the level recorded on the lot documentation.
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