- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
Tirzepatide + Vitamin B12
Dual GIP/GLP-1 agonist peptide co-formulated with methylcobalamin in one vial
- FormLyophilized co-formulated powder, sealed glass vial with flip-off seal
- Research areasIncretin receptor signalling, energy balance and glycaemic models, cofactor co-formulation stability
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
This blend combines two well-characterised components in a single vial: tirzepatide, a 39-residue acylated dual GIP and GLP-1 receptor agonist, and methylcobalamin, the methylated coenzyme form of vitamin B12. The two are chemically unrelated and act through entirely separate systems. Tirzepatide is a synthetic peptide engineered around a GIP backbone with a C20 fatty diacid chain that confers albumin binding and a long circulating half-life. Methylcobalamin is a deep-red cobalt-corrinoid cofactor for methionine synthase.
Blends of this kind exist in compounding and research practice because the two components address different variables in the same experimental system: the incretin arm drives the metabolic endpoints under study, while B12 is a co-formulated cofactor whose presence is one of the variables researchers may wish to hold constant or manipulate. Co-formulation also affects the formulation science itself — the corrinoid is strongly light-sensitive and colours the solution, which changes how a vial must be handled and how spectrophotometric assays are interpreted.
Specifications
Identity
- Peptide class
- Acylated dual GIP/GLP-1 receptor agonist (twincretin), 39 residues
Supply & purity
- Form
- Lyophilized co-formulated powder, sealed glass vial with flip-off seal
- Available sizes
- 10 mg tirzepatide + B12; 20 mg tirzepatide + B12
Additional detail
- Component 1
- Tirzepatide — dual GIP/GLP-1 receptor agonist peptide
- Component 2
- Methylcobalamin — methylated coenzyme form of vitamin B12
- Purity (peptide)
- ≥99% by HPLC; lot-matched COA available
- CAS number (tirzepatide)
- 2023788-19-2
- Molecular formula (tirzepatide)
- C225H348N48O68
- Molecular weight (tirzepatide)
- 4813.45 g/mol
- CAS number (methylcobalamin)
- 13422-55-4
- Molecular formula (methylcobalamin)
- C63H91CoN13O14P
- Molecular weight (methylcobalamin)
- 1344.38 g/mol
- Research areas
- Incretin receptor signalling, energy balance and glycaemic models, cofactor co-formulation stability
- Storage
- −20 °C lyophilized; 2–8 °C reconstituted, protected from light at all times
Questions about Tirzepatide + Vitamin B12
What exactly is in this vial?
Two components: tirzepatide, a 39-residue acylated dual GIP and GLP-1 receptor agonist peptide, and methylcobalamin, the methylated coenzyme form of vitamin B12. They are chemically unrelated and act through separate systems; the blend simply supplies both from one lyophilized preparation.
How does this differ from the plain tirzepatide vial?
The peptide is the same molecule with the same specifications. The difference is the co-formulated methylcobalamin, which colours the reconstituted solution, makes it strongly light-sensitive, and interferes with UV-based peptide quantification unless the components are chromatographically separated.
Why is light protection emphasised so heavily?
Methylcobalamin's cobalt-carbon bond is cleaved by light. Photolysis is fast enough to alter the preparation during ordinary bench work under bright lighting, so amber containers, foil wrapping and short exposure times are standard practice for any corrinoid-containing solution.
What purity documentation is provided?
The peptide component is third-party HPLC tested to at least 99% purity, with a lot-matched certificate of analysis available on request covering identity and purity. Keep the COA with your study record so material and data remain traceable to one another.
Which sizes are available?
Two: 10 mg of tirzepatide with B12, and 20 mg of tirzepatide with B12. The stated milligram figure refers to the peptide content; the cofactor is co-formulated at the level recorded on the lot documentation.
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