- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
SLU-PP-332
Small-molecule pan-ERR agonist studied as an exercise-mimetic probe
- FormLyophilized powder, sealed glass vial with flip-off seal
- Mol. weight290.27 g/mol
- Research areasMitochondrial biogenesis, fatty-acid oxidation, muscle endurance transcription
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
SLU-PP-332 is a synthetic small molecule that acts as an agonist at the estrogen-related receptors (ERR alpha, beta and gamma) — orphan nuclear receptors that regulate the transcriptional program governing mitochondrial biogenesis, oxidative phosphorylation and fatty-acid oxidation in muscle. Despite the name, the receptors are not estrogen receptors and do not bind estradiol; they were named for sequence similarity and act largely through coactivators of the PGC-1 family.
The compound drew attention because ERR activation switches on many of the same genes that endurance exercise induces, which led to it being described in the literature as an exercise mimetic. That framing deserves a caveat researchers state plainly: the published data come from cell systems and mouse studies, and there is no human evidence. That gap is exactly why the molecule is useful as a probe — it lets laboratories ask which parts of the exercise transcriptional response are downstream of ERR signaling and which are not.
Specifications
Identity
- CAS number
- 2098486-97-2
- Molecular weight
- 290.27 g/mol
Supply & purity
- Form
- Lyophilized powder, sealed glass vial with flip-off seal
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg
- Solubility
- DMSO for concentrated stocks; dilute into assay medium or buffer
Additional detail
- Compound class
- Small-molecule nuclear receptor agonist (non-peptide)
- Molecular target
- Estrogen-related receptors ERR alpha, beta and gamma
- Research areas
- Mitochondrial biogenesis, fatty-acid oxidation, muscle endurance transcription
- Evidence base
- Cell culture and rodent studies only; no human data published
- Storage (solid)
- −20 °C, sealed and protected from light and moisture
- Storage (in solution)
- 2–8 °C, protected from light; use within the study window
Questions about SLU-PP-332
Does SLU-PP-332 act on estrogen receptors?
No. The estrogen-related receptors share sequence similarity with estrogen receptors but do not bind estradiol and are functionally distinct. They act as constitutively active orphan nuclear receptors regulating oxidative metabolism genes, mainly through PGC-1 family coactivators.
What purity and documentation are supplied?
Each lot is HPLC tested to at least 99% purity, and a lot-matched certificate of analysis is available. The COA corresponds to the vial number shipped, so purity data stays traceable to the exact material used in your experiments.
Why is DMSO usually used instead of water?
SLU-PP-332 is a small hydrophobic molecule rather than a peptide, so aqueous solubility is limited. Preparing a concentrated DMSO stock and diluting into medium is the standard approach, with vehicle-matched controls run alongside every condition.
How should it be stored?
Keep the sealed solid at −20 °C, protected from light and moisture. Store prepared stocks at 2–8 °C, protected from light, and use within your documented study window. Aliquot so that stocks are not repeatedly warmed and cooled.
Related
