- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Thymogen (Glu-Trp)
Synthetic Glu-Trp dipeptide studied in thymic immune regulation models
- FormLyophilized powder, sealed glass vial with flip-off seal
- Mol. weight333.34 g/mol
- Research areasLymphocyte differentiation, thymic immune signalling, cytokine expression models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Thymogen is a synthetic dipeptide, L-glutamyl-L-tryptophan, and one of the shortest peptides in the immune research catalog — just two residues, Glu-Trp, with formula C16H19N3O5 and a mass of 333.34 g/mol under CAS 103213-49-6. It emerged from Soviet-era work at the Military Medical Academy in Leningrad, where researchers fractionating thymic extracts sought the minimal active sequence rather than the whole polypeptide mixture, and identified this pair as a candidate.
That heritage places Thymogen in the same lineage as Thymalin and the broader family of peptide bioregulators associated with Vladimir Khavinson and Vyacheslav Morozov: short synthetic sequences intended to reproduce the activity attributed to a tissue-derived extract in a defined, reproducible chemical form. Where Thymalin is a peptide complex isolated from calf thymus, Thymogen is a single synthetic molecule of exactly known structure — which is what makes it a cleaner reagent for controlled work.
Specifications
Identity
- CAS number
- 103213-49-6
- Molecular formula
- C16H19N3O5
- Molecular weight
- 333.34 g/mol
- Amino acid sequence
- H-Glu-Trp-OH (L-glutamyl-L-tryptophan)
- Chain length
- 2 amino acids (dipeptide)
- Peptide class
- Synthetic thymic peptide bioregulator
Supply & purity
- Form
- Lyophilized powder, sealed glass vial with flip-off seal
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 10 mg, 20 mg
- Solubility
- Readily soluble in water and bacteriostatic water
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Also known as
- Thymogen, Glu-Trp, EW dipeptide
- Research areas
- Lymphocyte differentiation, thymic immune signalling, cytokine expression models
Questions about Thymogen (Glu-Trp)
What is Thymogen?
Thymogen is a synthetic dipeptide, L-glutamyl-L-tryptophan (Glu-Trp), developed from Soviet-era research that fractionated thymus extracts to find the shortest sequence retaining activity. It has a defined structure of just two amino acids, CAS 103213-49-6 and a mass of 333.34 g/mol.
How does it differ from Thymalin?
Thymalin is a peptide complex extracted from calf thymus — a mixture whose exact composition varies between preparations. Thymogen is a single synthetic molecule of known structure, so identity and purity can be verified analytically lot after lot.
How is purity verified and is a COA supplied?
Each lot is analysed by reversed-phase HPLC to at least 99% purity, with identity confirmed against the expected 333.34 g/mol mass. A certificate of analysis matched to the lot number on your vial is available on request before or after purchase.
Which vial size should a laboratory choose?
The 10 mg vial covers assay development and short pilots, while 20 mg reduces the number of vial openings across longer or multi-arm work. Since the peptide is inexpensive to synthesise, most laboratories choose based on study length rather than cost per milligram.
Why does light matter for this peptide?
The tryptophan residue absorbs strongly in the ultraviolet and is prone to photo-oxidation. That absorbance is convenient for quantifying the peptide near 280 nm, but it also means solutions left in clear vessels under laboratory lighting can degrade, so amber or foil-wrapped storage is standard.
How should it be stored and reconstituted?
Keep the lyophilized vial at −20 °C, sealed and dry. Reconstitute with bacteriostatic or sterile water, swirling rather than shaking; it dissolves readily. Hold the reconstituted solution at 2–8 °C protected from light and use it within the planned study window.
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