- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Thymosin Alpha-1
Acetylated 28-residue thymic peptide from prothymosin alpha
- FormLyophilized powder, sealed glass vial with crimped stopper
- Mol. weight3108.30 g/mol
- Research areasT cell maturation, Toll-like receptor signalling, antiviral and vaccine adjuvant models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Thymosin Alpha-1 is a twenty-eight amino acid, N-terminally acetylated peptide corresponding to the first 28 residues of prothymosin alpha. It was isolated from calf thymus extract in the 1970s during the effort to identify the active constituents of thymosin fraction 5, and it remains the best-characterised single molecule to emerge from that work.
Our material is produced by solid-phase synthesis, purified by reversed-phase HPLC to at least 99% and supplied as a lyophilized powder in sealed 5 mg, 10 mg and 20 mg vials with a lot-matched certificate of analysis. Research use concentrates on T cell maturation, Toll-like receptor signalling and immune modulation. Sold for laboratory research only.
Specifications
Identity
- CAS number
- 62304-98-7
- Molecular formula
- C129H215N33O55
- Molecular weight
- 3108.30 g/mol
- Amino acid sequence
- Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
- Chain length
- 28 amino acids, N-terminally acetylated
- Peptide class
- Thymic immunomodulatory peptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial with crimped stopper
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg, 20 mg
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light, used within the study window
Additional detail
- Parent protein
- Prothymosin alpha (residues 1–28)
- Research areas
- T cell maturation, Toll-like receptor signalling, antiviral and vaccine adjuvant models
Questions about Thymosin Alpha-1
What is Thymosin Alpha-1?
It is a synthetic twenty-eight amino acid peptide with an acetylated N-terminus, matching the first 28 residues of prothymosin alpha. Originally identified in calf thymus extract, it is supplied here as a lyophilized research powder for immune signalling studies.
How is it different from Thymalin or Thymulin?
Thymosin Alpha-1 is a single defined molecule with a known sequence and mass. Thymalin is a mixture of thymic polypeptides rather than one compound, and Thymulin is a separate nine-residue peptide whose activity is described as zinc-dependent. All three come from thymic research but are chemically distinct.
What purity do you supply and is a COA included?
Each lot is purified and analysed by reversed-phase HPLC to at least 99% with mass-spectrometric confirmation against the expected 3108.30 g/mol mass. A certificate of analysis matched to the lot number on your vial is available on request at any time.
How should it be stored after reconstitution?
Hold the solution at 2–8 °C, protected from light, and use it within the planned study window rather than storing indefinitely. Aliquot immediately after reconstitution so that individual tubes are thawed once rather than the whole stock being cycled repeatedly.
Can this vial be used in humans?
No. Despite the existence of approved products in other countries, this material is sold as a research chemical for laboratory investigation by qualified personnel. It is not a medicine, is not approved for human or veterinary administration here, and carries no dosing guidance.
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