- ≥99% by HPLC with mass-spectrometric identity check; COA per lot
- Lot-matched certificate of analysis
- Ships next business day, tracked
Argireline (Acetyl Hexapeptide-8)
Acetyl hexapeptide-8 — the EEMQRR cosmetic signal peptide, 10 mg and 50 mg
- FormWhite lyophilized powder in a sealed glass vial
- Mol. weight888.99 g/mol
- Research areasSNARE assembly, exocytosis interference, expression-line formulation studies
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Argireline is the trade name for acetyl hexapeptide-8, a six-residue peptide with the sequence Glu-Glu-Met-Gln-Arg-Arg, acetylated at the N-terminus and amidated at the C-terminus. It was originally described as acetyl hexapeptide-3 and remains one of the most extensively studied cosmetic signal peptides, in large part because it is small, water-soluble and cheap to characterise. The sequence is taken from the N-terminal region of SNAP-25, a component of the SNARE complex responsible for vesicle docking and fusion at the synapse.
In research settings the peptide is used to probe interference with SNARE assembly from outside the cell, and as a benchmark ingredient in topical formulation studies that measure the appearance of dynamic lines by profilometry or image analysis. It is the reference point against which newer analogs such as SNAP-8 are compared, so bench programmes commonly run the two together in the same vehicle and at matched molar concentrations.
MyPeptide stocks Argireline as a lyophilized powder in 10 mg and 50 mg vials, third-party tested to ≥99% by HPLC with a lot-matched certificate of analysis, dispatched from the United States for laboratory research use only.
Specifications
Identity
- CAS number
- 616204-22-9
- Molecular formula
- C34H60N14O12S
- Molecular weight
- 888.99 g/mol
- Amino acid sequence
- Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
- Peptide class
- Cosmetic signal peptide; SNAP-25 N-terminal fragment analog
Supply & purity
- Form
- White lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC with mass-spectrometric identity check; COA per lot
- Available sizes
- 10 mg, 50 mg
- Solubility
- Freely soluble in water and bacteriostatic water
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed, away from light and moisture
Additional detail
- INCI name
- Acetyl Hexapeptide-8 (formerly acetyl hexapeptide-3)
- Research areas
- SNARE assembly, exocytosis interference, expression-line formulation studies
- Storage (in solution)
- 2–8 °C, short-term; methionine is oxidation-sensitive
Questions about Argireline (Acetyl Hexapeptide-8)
What is Argireline?
Argireline is the commercial name for acetyl hexapeptide-8, a six-amino-acid peptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 copied from the N-terminal region of SNAP-25. It is one of the most-studied cosmetic signal peptides and is widely used as a reference material in formulation and SNARE-assembly research.
Is acetyl hexapeptide-8 the same as acetyl hexapeptide-3?
Yes. The ingredient was originally listed as acetyl hexapeptide-3 and later renamed acetyl hexapeptide-8 in INCI nomenclature. Older papers and datasheets use the earlier name for the identical sequence, which is worth knowing when reconciling literature values with a current certificate of analysis.
Is this lot third-party tested, and can I see the COA?
Yes. Every production lot is analysed by an independent laboratory for identity and purity — HPLC with mass-spectrometric confirmation — and the lot-matched certificate of analysis is available on request before purchase. The COA states the lot number, assay result and test date so it can be filed with your experimental records.
How does it compare with SNAP-8?
SNAP-8 is the same core sequence with two extra residues at the C-terminus, giving an octapeptide. Comparative bench work looks at affinity for the SNARE interface, aqueous stability and behaviour in identical vehicles. Neither peptide substitutes for the other in a study design; they are usually run in parallel.
What sizes and vial contents are offered?
Argireline is supplied in 10 mg and 50 mg lyophilized vials containing peptide only, with no diluent, carrier or preservative. The 10 mg size suits receptor and assay work; the 50 mg size is aimed at repeated formulation trials where larger volumes of stock solution are needed.
How should it be stored and dissolved?
Store the sealed lyophilate at −20 °C, protected from light and moisture. It dissolves freely in water or bacteriostatic water. Because of the oxidation-prone methionine, prepare solutions close to the time of use, keep them at 2–8 °C and avoid repeated freeze–thaw cycles.
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