- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
GHK Basic (Tripeptide-1)
Copper-free Gly-His-Lys tripeptide for matrix and fibroblast research
- FormWhite to off-white lyophilized powder, sealed glass vial
- Mol. weight340.38 g/mol
- Research areasFibroblast signaling, matrix turnover, copper coordination, protease regulation and reactive-carbonyl chemistry
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
GHK Basic is the copper-free tripeptide glycyl-L-histidyl-L-lysine, also called Tripeptide-1. The distinction from GHK-Cu is chemical rather than cosmetic: GHK Basic contains the three-amino-acid ligand by itself, while GHK-Cu is a coordinated copper(II) complex with different mass, color and redox behavior. The uncomplexed peptide is a white to off-white powder rather than the characteristic blue of the copper form. Cosmetic-ingredient nomenclature keeps the same split, listing the free peptide as Tripeptide-1 and the complex as Copper Tripeptide-1, which is worth checking on supplier paperwork before two datasets are compared.
GHK occurs naturally in human plasma and also appears as a sequence within extracellular-matrix proteins; it was first described in the early 1970s as a low-molecular-weight activity separated from human plasma. Cell and biochemical research has examined its copper-binding equilibrium, fibroblast signaling, extracellular-matrix gene expression, protease regulation and reactive-carbonyl chemistry. Because trace copper in media can convert part of a nominally copper-free preparation into GHK-Cu, careful studies measure or control metal content.
Specifications
Identity
- CAS number
- 49557-75-7
- Molecular formula
- C14H24N6O4
- Molecular weight
- 340.38 g/mol
- Amino acid sequence
- Gly-His-Lys (GHK)
- Peptide class
- Endogenous matrix-associated tripeptide and copper-binding ligand
Supply & purity
- Form
- White to off-white lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 50 mg, 200 mg
- Solubility
- Water-soluble; use metal-controlled buffers for copper-comparison studies
Additional detail
- Also known as
- Tripeptide-1, glycyl-L-histidyl-L-lysine, GHK free peptide
- Copper status
- No coordinated copper added; trace-metal conditions remain an assay variable
- Research areas
- Fibroblast signaling, matrix turnover, copper coordination, protease regulation and reactive-carbonyl chemistry
- Storage
- −20 °C lyophilized; protect from moisture and use refrigerated solutions within the study window
Questions about GHK Basic (Tripeptide-1)
Is GHK Basic the same as GHK-Cu?
No. GHK Basic is the copper-free Gly-His-Lys ligand. GHK-Cu is the coordinated copper(II) complex, which has a different molecular mass, blue color and redox chemistry. They need separate controls and should not share one product identity.
What is Tripeptide-1?
Tripeptide-1 is the cosmetic and catalog name commonly used for glycyl-L-histidyl-L-lysine, abbreviated GHK. The product here is the free peptide with sequence Gly-His-Lys and CAS 49557-75-7.
Why compare GHK Basic with Pal-GHK?
Pal-GHK adds a sixteen-carbon palmitoyl group to the same peptide core. That lipid tail changes solubility, membrane partitioning and surface adsorption. Running both forms helps isolate the effect of lipidation from the underlying GHK sequence.
What purity and documentation are provided?
The material is released at ≥99% purity by reversed-phase HPLC, and a certificate of analysis matched to the vial's lot is available. Studies focused on copper speciation should perform their own metal analysis as well.
What sizes are available?
GHK Basic is listed in 50 mg and 200 mg sealed research vials. Those are the size points observed in current specialist peptide catalogs and support both cell-culture and formulation-development work.
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