- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
Hyaluronic Acid (Sodium Hyaluronate)
Sodium hyaluronate glycosaminoglycan for skin, matrix and viscosity research
- FormLyophilized sodium hyaluronate powder, or pre-mixed 1% aqueous solution
- Mol. weightPolydisperse — a chain-length distribution rather than a single mass; see the lot COA
- Research areasSkin hydration and dermal matrix models, hydrogel scaffolds, synovial viscosity, wound-model studies
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Hyaluronic acid is not a peptide at all — it is a linear glycosaminoglycan built from a repeating disaccharide of D-glucuronic acid and N-acetyl-D-glucosamine joined by alternating beta-1,3 and beta-1,4 linkages. That simple, unsulfated backbone is the same in every tissue that makes it, from skin dermis and synovial fluid to the vitreous humour of the eye; what changes between sources is chain length, and chain length is what drives most of its physical and biological behaviour. Material supplied for laboratory work is normally the sodium salt, sodium hyaluronate, which is far easier to dry, weigh and redissolve than the free acid.
Because the polymer carries one carboxylate per disaccharide, it binds a very large volume of water relative to its mass and forms viscoelastic solutions at low concentration. Researchers use those properties directly — as a viscosity modifier, a hydrogel component or a matrix mimic — and also study the polymer as a signalling molecule, since fragments of different molecular weight interact differently with the CD44, RHAMM and LYVE-1 receptors and with hyaluronidase enzymes.
Specifications
Identity
- CAS number
- 9067-32-7 (sodium hyaluronate)
- Molecular weight
- Polydisperse — a chain-length distribution rather than a single mass; see the lot COA
Supply & purity
- Form
- Lyophilized sodium hyaluronate powder, or pre-mixed 1% aqueous solution
- Available sizes
- 5 mg lyophilized; 2 mL of 1% solution
- Solubility
- Water and aqueous buffers; dissolves slowly, hydrate without vigorous shear
Additional detail
- Chemical class
- Non-sulfated linear glycosaminoglycan (polysaccharide)
- Repeating unit
- D-glucuronic acid + N-acetyl-D-glucosamine, beta-1,3 and beta-1,4 linked
- Solution behaviour
- Highly hydrophilic; forms viscoelastic, shear-thinning solutions at low concentration
- Known receptors
- CD44, RHAMM (HMMR), LYVE-1
- Degrading enzymes
- Hyaluronidases (HYAL1, HYAL2, PH-20) and reactive oxygen species
- Research areas
- Skin hydration and dermal matrix models, hydrogel scaffolds, synovial viscosity, wound-model studies
- Storage (powder)
- 2–8 °C or cooler, sealed and protected from moisture
- Storage (solution)
- 2–8 °C, protected from light; do not freeze-thaw repeatedly
Questions about Hyaluronic Acid (Sodium Hyaluronate)
Is this hyaluronic acid or sodium hyaluronate?
The material supplied is sodium hyaluronate, the sodium salt of hyaluronic acid. It is the standard laboratory form because it dries to a stable powder and redissolves more readily than the free acid. In solution the two are chemically equivalent at physiological pH.
What molecular weight is the material?
Hyaluronan is polydisperse, so it is described by a chain-length distribution rather than one number. The lot-matched certificate of analysis is the authoritative record for the batch you receive, and it is worth quoting that range in any write-up because reported effects often depend on chain size.
Is a certificate of analysis available?
Yes. Every lot is tested and supplied with a matching COA covering identity and purity. Request it with your order or afterwards by lot number, and keep it with your experimental records so the material grade can be reported alongside your results.
Which format should a laboratory choose?
The 5 mg lyophilized powder suits work where you need to control buffer, ionic strength and final concentration yourself. The 2 mL 1% solution suits formulation, viscosity and topical-model work where a consistent, ready-made stock removes a preparation variable.
How is it dissolved without lumps?
Scatter the powder across the surface of the aqueous phase and leave it to swell before mixing, rather than adding it to an already-stirring vessel. Gentle agitation over a longer period gives a clear solution; aggressive shear or sonication dissolves it faster but cleaves the polymer chains.
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