- ≥99% by HPLC; mass-based identity confirmation; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Tissue Repair & Healing Peptides
B7-33 (Relaxin-2 B-Chain Analog)
Linear 27-residue relaxin-2 B-chain analog studied as an RXFP1 agonist
- FormLyophilized powder, sealed glass research vial
- Research areasRXFP1 signaling bias, fibroblast biology, extracellular-matrix turnover, fibrosis and vascular-response models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
B7-33 is a synthetic, single-chain peptide derived from the receptor-binding region of the human relaxin-2 B chain. Its 27-residue sequence retains the arginine-rich motif used by relaxin family peptide receptor 1 (RXFP1) while avoiding the two-chain, three-disulfide architecture of the native hormone. The name records that span, corresponding to positions 7 through 33 of the B chain, and because the sequence carries no cysteine it requires no oxidative folding step. The result is a linear research analog that is easier to synthesize and characterize than full relaxin-2.
Specifications
Identity
- Amino acid sequence
- Val-Ile-Lys-Leu-Ser-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Ser-Gly-Met-Ser-Thr-Trp-Ser-Lys-Arg-Ser-Leu
- Chain length
- 27 amino acids
- Peptide class
- Linear human relaxin-2 B-chain analog
Supply & purity
- Form
- Lyophilized powder, sealed glass research vial
- Purity
- ≥99% by HPLC; mass-based identity confirmation; lot-matched COA available
- Solubility
- Water-soluble research peptide; buffer compatibility should be validated for the selected assay
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
Additional detail
- Available size
- 6 mg
- Primary research target
- Relaxin family peptide receptor 1 (RXFP1)
- Research areas
- RXFP1 signaling bias, fibroblast biology, extracellular-matrix turnover, fibrosis and vascular-response models
- Distinction
- Not native relaxin-2 or serelaxin; contains one engineered linear chain and no disulfide-linked A chain
- Storage (in solution)
- 2–8 °C for a defined study window; aliquot for longer holds
Questions about B7-33 (Relaxin-2 B-Chain Analog)
What is B7-33?
B7-33 is a 27-amino-acid synthetic analog derived from the B chain of human relaxin-2. It retains the main RXFP1-binding motif in one linear chain, making it structurally simpler than native relaxin, which has separate A and B chains joined by disulfide bonds.
What does B7-33 target in research models?
Its primary reported target is RXFP1, the cognate receptor for relaxin-2. Studies examine receptor signaling, fibroblast matrix output, fibrotic remodeling and vascular endpoints, with results depending on cell type, receptor density and experimental design.
What purity documentation is available?
The peptide is released at ≥99% purity by reversed-phase HPLC with identity checked against the expected mass. A certificate of analysis matched to the vial's lot number is available for study records.
How should B7-33 be stored?
Keep the sealed lyophilized vial at −20 °C, dry and protected from light. After preparation, refrigerate short-term working stocks and use aliquots for longer study windows so the same solution is not repeatedly frozen and thawed.
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