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Pentosan Polysulfate Sodium

Semi-synthetic sulfated xylan polysaccharide, 100 mg and 250 mg vials

In stock·2 formats available·CAS 37319-17-8

$72Range $72 – $140

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100 mg$72250 mg$140

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FormLyophilized powder, sealed glass vial
Mol. weightPolydisperse; average molecular weight typically reported in the 4,000–6,000 Da range
Research areasCartilage and connective-tissue matrix, urothelial and epithelial barrier models, glycocalyx biology, growth-factor and protease binding

Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.

Overview

Pentosan polysulfate sodium (PPS) is not a peptide at all — it is a semi-synthetic sulfated polysaccharide, made by chemically sulfating xylan extracted from beechwood hemicellulose. The result is a linear chain of β-1,4-linked xylopyranose units carrying sulfate ester groups, with a small proportion of 4-O-methylglucuronic acid side residues. Average chain length is modest by polysaccharide standards, typically in the region of 4–6 kDa, and it is that combination of short chain and dense negative charge that gives the molecule its heparin-like character without heparin's anticoagulant potency.

Researchers work with PPS because it behaves as a glycosaminoglycan mimetic. Its sulfation pattern lets it bind the same cationic protein surfaces that native GAGs such as heparan sulfate and chondroitin sulfate engage — growth factors, complement components, proteases and cartilage matrix proteins. That has made it a recurring tool compound in cartilage and connective-tissue models, in studies of epithelial barrier function, and in work on the glycocalyx.

Specifications

Identity

CAS number: 37319-17-8
Molecular weight: Polydisperse; average molecular weight typically reported in the 4,000–6,000 Da range

Supply & purity

Form: Lyophilized powder, sealed glass vial
Purity: Third-party tested; lot-matched COA available
Available sizes: 100 mg, 250 mg
Solubility: Freely soluble in water; gives a clear, slightly viscous solution

Handling & storage

Storage (lyophilized): 2–8 °C or below, sealed, protected from light and moisture — the powder is hygroscopic
Storage (reconstituted): 2–8 °C, used within the study window

Additional detail

Chemical class: Semi-synthetic sulfated polysaccharide (sulfated xylan), sodium salt
Source material: Xylan from beechwood hemicellulose, chemically sulfated
Backbone: β-1,4-linked xylopyranose units with sulfate ester substitution and occasional 4-O-methylglucuronic acid side residues
Also known as: PPS, sodium pentosan polysulfate, xylan polysulfate
Functional description: Glycosaminoglycan mimetic; low-affinity, heparin-like polyanion
Research areas: Cartilage and connective-tissue matrix, urothelial and epithelial barrier models, glycocalyx biology, growth-factor and protease binding

Questions about Pentosan Polysulfate Sodium

Is pentosan polysulfate a peptide?

No. Despite sitting in the tissue-repair category alongside peptides such as BPC-157 and TB-500, PPS is a sulfated polysaccharide — a xylan backbone of β-1,4-linked xylopyranose units carrying sulfate esters. It is grouped by research area, not by chemical class.

Why is no exact molecular weight given?

Because the material is polydisperse. Sulfating a natural xylan produces a distribution of chain lengths and sulfation densities rather than a single species, so lots are specified by average molecular weight — typically around 4,000–6,000 Da — plus degree of sulfation.

What purity documentation is provided?

Material is third-party tested and a lot-matched certificate of analysis is available on request. For a polysaccharide the COA reports identity, average molecular weight and sulfur or sulfate content rather than the HPLC peptide-purity figure used for synthetic peptides in this catalogue.

How should it be reconstituted and stored?

The powder is hygroscopic — warm a vial to room temperature before opening to avoid condensation. It dissolves freely in water and aqueous buffers; add diluent gently down the vial wall and swirl rather than shake. Store sealed powder at 2–8 °C or below and solutions at 2–8 °C.