- ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
Epitalon (Epithalon) Peptide
Ala-Glu-Asp-Gly pineal tetrapeptide studied in telomere and aging models
- FormLyophilized powder, sealed glass vial
- Mol. weight390.35 g/mol
- Research areasTelomerase activity, circadian and pineal signaling, cellular senescence models
Overview
Epitalon, also written epithalon or epithalamin, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed in St. Petersburg by Vladimir Khavinson's group as a short synthetic analogue of epithalamin, a peptide preparation originally extracted from the pineal gland. At 390.35 g/mol it is one of the smallest peptides in common research use, and it belongs to the class of Russian bioregulator peptides.
Our epitalon is made by solid-phase synthesis, purified by preparative HPLC and supplied as a lyophilized powder in a sealed vial. Every lot is tested for purity and identity with a Certificate of Analysis available before purchase.
Specifications
Identity
- CAS number
- 307297-39-8
- Molecular formula
- C14H22N4O9
- Molecular weight
- 390.35 g/mol
- Amino acid sequence
- H-Ala-Glu-Asp-Gly-OH
- Peptide class
- Synthetic bioregulator tetrapeptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Available sizes
- 10 mg, 20 mg, 50 mg, 100 mg
- Solubility
- Readily soluble in water and bacteriostatic water
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Also known as
- Epithalon, epithalamin analogue, AEDG peptide
- Research areas
- Telomerase activity, circadian and pineal signaling, cellular senescence models
Working out the concentration
The vial sizes above — 10 mg, 20 mg, 50 mg, 100 mg — describe a mass of material, not a strength. Choose a diluent volume, work it out with the reconstitution calculator, and you have the concentration for your own vial of Epitalon (Epithalon) plus the volume that carries any mass you want to withdraw.
If the protocol asks for a molar concentration, the molar concentration calculator converts between 390.35 g/mol, the mass you weigh out and the volume you dissolve it in.
Certificate of analysis
Every lot of Epitalon (Epithalon) is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Epitalon (Epithalon)
What is epitalon?
Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, developed as a short analogue of the pineal preparation epithalamin. It is used in laboratory research on telomerase activity, circadian signaling and cellular senescence models.
Is epitalon the same as epithalon?
Yes. Epitalon, epithalon and the AEDG peptide are different spellings and designations for the same four-residue molecule. Epithalamin refers to the older pineal extract preparation rather than the defined synthetic tetrapeptide.
How is purity verified?
Every lot is tested by reverse-phase HPLC for purity of ≥99% and by mass spectrometry for identity against the expected 390.35 g/mol mass. The lot-matched Certificate of Analysis is available on this page before you order.
What sizes are available?
Epitalon is supplied in 10 mg, 20 mg and 50 mg lyophilized vials. Because the molecule is small, one milligram represents a comparatively large molar quantity, so many laboratories find the 10 mg vial sufficient for pilot work.
How should epitalon be stored?
Keep the lyophilized vial at −20 °C, protected from light and moisture. After reconstitution store at 2–8 °C, protect from light, and use within your validated study window; aliquoting reduces degradation from repeated temperature cycling.
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