- ≥99% by HPLC; lot-matched COA
- Lot-matched certificate of analysis
- Ships next business day, tracked
NAD+
Nicotinamide adenine dinucleotide coenzyme, 500 mg and 1000 mg vials
- FormLyophilized powder, sealed glass vial
- Mol. weight663.43 g/mol
- Research areasCellular redox state, DNA repair signaling, mitochondrial metabolism, aging biology
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a dinucleotide coenzyme rather than a peptide. It consists of nicotinamide mononucleotide joined to adenosine monophosphate through a pyrophosphate bridge, and it is present in every living cell as the central electron carrier of catabolic metabolism. In its oxidized state it accepts a hydride to become NADH; the ratio between the two forms is one of the most-measured indicators of cellular redox state.
Specifications
Identity
- CAS number
- 53-84-9
- Molecular formula
- C21H27N7O14P2
- Molecular weight
- 663.43 g/mol
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Available sizes
- 500 mg, 1000 mg
- Solubility
- Freely soluble in water; solutions are acidic and best buffered
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used promptly; NAD+ hydrolyzes at alkaline pH
Additional detail
- Chemical class
- Dinucleotide coenzyme (free acid form)
- Also known as
- Nicotinamide adenine dinucleotide, oxidized NAD, DPN
- Enzyme substrate for
- Sirtuins (SIRT1–7), PARP family, CD38/CD157
- Research areas
- Cellular redox state, DNA repair signaling, mitochondrial metabolism, aging biology
Questions about NAD+
Is NAD+ a peptide?
No. NAD+ is a dinucleotide coenzyme built from nicotinamide mononucleotide and adenosine monophosphate joined by a pyrophosphate bridge. It is catalogued alongside research peptides because laboratories studying mitochondrial and aging biology commonly use both.
What is the difference between NAD+ and NADH?
They are the oxidized and reduced forms of the same coenzyme. NAD+ accepts a hydride to become NADH during catabolic reactions, and the ratio between them is used as a readout of cellular redox state in metabolic research.
Is this NAD+ third-party tested?
Yes. Every lot is analyzed by HPLC for purity of ≥99%, and a lot-matched Certificate of Analysis is available on this page before purchase so you can confirm identity and purity against your own acceptance criteria.
How should NAD+ solutions be handled?
Dissolve in water or a suitable buffer, keep the pH near or below neutral, and use solutions promptly. NAD+ hydrolyzes under alkaline conditions and degrades with warmth, so cold storage, light protection and aliquoting all help preserve assay-grade material.
How does NAD+ compare with NMN or nicotinamide riboside?
NMN and nicotinamide riboside are precursors that cells convert into NAD+ through the salvage pathway, whereas NAD+ is the intact coenzyme. Comparative studies of precursor loading versus direct coenzyme supply are an active research topic.
What sizes are offered?
NAD+ is supplied in 500 mg and 1000 mg lyophilized vials. Larger quantities than a typical peptide are usual because enzyme assays and cell-culture work consume the coenzyme at millimolar to micromolar concentrations.
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