- ≥99% by HPLC; lot-matched COA
- Lot-matched certificate of analysis
- Ships next business day, tracked
FOXO4-DRI
D-retro-inverso FOXO4 peptide used as a senolytic tool compound
- FormLyophilized powder, sealed glass vial
- Mol. weight≈6053 g/mol (see lot COA for exact value)
- Research areasCellular senescence, FOXO4–p53 interaction, senolytics, SASP markers
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
FOXO4-DRI is a synthetic peptide built from a fragment of the FOXO4 transcription factor and re-engineered as a D-retro-inverso analogue: the sequence is reversed and every residue is a D-amino acid, so the side-chain topology of the original L-peptide is approximately preserved while protease susceptibility drops sharply. A cell-penetrating segment is included so the construct can reach intracellular targets in culture.
Supplied as a lyophilized powder in a sealed vial with lot-matched analytical documentation. Because it is a long, highly charged peptide, laboratories should plan reconstitution and storage carefully. For laboratory research use only.
Specifications
Identity
- CAS number
- 2114879-72-6
- Molecular weight
- ≈6053 g/mol (see lot COA for exact value)
- Peptide class
- Cell-penetrating senolytic peptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Solubility
- Water or bacteriostatic water; sterile-filter before cell work
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C for short-term use; aliquot and freeze for longer studies
Additional detail
- Available size
- 10 mg
- Chirality
- All-D amino acids, retro-inverso orientation
- Parent protein
- FOXO4 forkhead box O transcription factor
- Research areas
- Cellular senescence, FOXO4–p53 interaction, senolytics, SASP markers
Questions about FOXO4-DRI
What is FOXO4-DRI?
FOXO4-DRI is a synthetic D-retro-inverso peptide derived from the FOXO4 transcription factor. It is used in laboratory research as a senolytic tool compound that interferes with the FOXO4–p53 interaction described in senescent cells.
What does D-retro-inverso mean?
The peptide's sequence is written in reverse and every residue is a D-amino acid rather than the natural L form. This preserves an approximate side-chain topology while making the backbone resistant to proteases, which extends the molecule's usable half-life in experiments.
Is this lot third-party tested?
Yes. Each lot is analyzed by HPLC for purity and by mass spectrometry for identity, with a lot-matched Certificate of Analysis available before purchase. Review the net peptide content on the COA when calculating working concentrations.
What size is available?
FOXO4-DRI is offered as a single 10 mg lyophilized vial. Given the peptide's molecular weight of roughly 6053 g/mol, that mass corresponds to a far smaller molar quantity than 10 mg of a short peptide such as epitalon.
How should it be reconstituted?
Sterile or bacteriostatic water is standard; add it slowly along the vial wall and swirl rather than shake. Because the peptide is long and charged, allow additional dissolution time and use low-binding labware to reduce adsorption losses.
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