- ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
FOXO4-DRI Peptide
D-retro-inverso FOXO4 peptide used as a senolytic tool compound
- FormLyophilized powder, sealed glass vial
- Mol. weight≈6053 g/mol (see lot COA for exact value)
- Research areasCellular senescence, FOXO4–p53 interaction, senolytics, SASP markers
Overview
FOXO4-DRI is a synthetic peptide built from a fragment of the FOXO4 transcription factor and re-engineered as a D-retro-inverso analogue: the sequence is reversed and every residue is a D-amino acid, so the side-chain topology of the original L-peptide is approximately preserved while protease susceptibility drops sharply. A cell-penetrating segment is included so the construct can reach intracellular targets in culture.
Supplied as a lyophilized powder in a sealed vial with lot-matched analytical documentation. Because it is a long, highly charged peptide, laboratories should plan reconstitution and storage carefully.
Specifications
Identity
- CAS number
- 2114879-72-6
- Molecular weight
- ≈6053 g/mol (see lot COA for exact value)
- Peptide class
- Cell-penetrating senolytic peptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Solubility
- Water or bacteriostatic water; sterile-filter before cell work
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C for short-term use; aliquot and freeze for longer studies
Additional detail
- Available size
- 10 mg
- Chirality
- All-D amino acids, retro-inverso orientation
- Parent protein
- FOXO4 forkhead box O transcription factor
- Research areas
- Cellular senescence, FOXO4–p53 interaction, senolytics, SASP markers
Working out the concentration
Reconstitution is where the arithmetic lives. The same vial made up with 1 mL or with 3 mL of diluent gives three-fold different numbers, which is why a reconstitution volume calculator is more use here than a fixed table: enter the vial mass and your diluent volume and read the concentration back.
For work specified in µM or nM rather than mg/mL, feed ≈6053 g/mol (see lot COA for exact value) and your volume into the peptide molarity calculator.
Certificate of analysis
Every lot of FOXO4-DRI is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about FOXO4-DRI
What is FOXO4-DRI?
FOXO4-DRI is a synthetic D-retro-inverso peptide derived from the FOXO4 transcription factor. It is used in laboratory research as a senolytic tool compound that interferes with the FOXO4–p53 interaction described in senescent cells.
What does D-retro-inverso mean?
The peptide's sequence is written in reverse and every residue is a D-amino acid rather than the natural L form. This preserves an approximate side-chain topology while making the backbone resistant to proteases, which extends the molecule's usable half-life in experiments.
Is this lot third-party tested?
Yes. Each lot is analyzed by HPLC for purity and by mass spectrometry for identity, with a lot-matched Certificate of Analysis available before purchase. Review the net peptide content on the COA when calculating working concentrations.
What size is available?
FOXO4-DRI is offered as a single 10 mg lyophilized vial. Given the peptide's molecular weight of roughly 6053 g/mol, that mass corresponds to a far smaller molar quantity than 10 mg of a short peptide such as epitalon.
How should it be reconstituted?
Sterile or bacteriostatic water is standard; add it slowly along the vial wall and swirl rather than shake. Because the peptide is long and charged, allow additional dissolution time and use low-binding labware to reduce adsorption losses.
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