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HGH (Somatropin) — Prescription Reference
Recombinant human growth hormone — prescription-only reference listing
- Mol. weight≈22,124 Da (22.1 kDa)
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Prescription-only reference listing. Somatropin is a prescription biologic medicine. It appears in this institutional catalogue as a reference entry so that clinics, pharmacies and laboratories can identify the molecule, its presentations, its approved indications and its storage requirements. It is supplied only against a valid prescription or documented institutional authorisation. No sourcing route, dosing schedule or administration guidance is provided on this page.
Chemically, somatropin is recombinant human growth hormone: a single-chain protein of 191 amino acids with two intramolecular disulfide bridges and a molecular weight of roughly 22.1 kDa. It is produced by recombinant DNA technology, historically in Escherichia coli and also in mammalian cell systems, and its amino acid sequence is identical to the pituitary-derived hormone. Potency is expressed either in milligrams or in international units, with the conventional labelling equivalence of 1 mg to approximately 3 IU — which is why vials and cartridges in this listing are described in IU.
Somatropin acts on the growth hormone receptor, a class I cytokine receptor. Receptor engagement triggers JAK2 activation and STAT5 signalling, and a large part of the downstream biology is mediated by hepatic and local production of insulin-like growth factor 1. Growth hormone also exerts direct effects on adipocyte lipolysis and on carbohydrate handling. Listed here for reference only.
Specifications
Identity
- CAS number
- 12629-01-5
- Molecular weight
- ≈22,124 Da (22.1 kDa)
Additional detail
- Regulatory status
- Prescription-only biologic medicine (Rx); supplied solely against valid prescription or institutional authorisation
- Generic name
- Somatropin (recombinant human growth hormone)
- Also known as
- rhGH, hGH, growth hormone, GH
- Structure
- Single polypeptide chain of 191 amino acids with two intramolecular disulfide bonds
- Production
- Recombinant DNA technology in bacterial or mammalian expression systems
- Molecular target
- Growth hormone receptor (class I cytokine receptor); JAK2/STAT5 signalling
- Key mediator
- Insulin-like growth factor 1 (IGF-1), produced hepatically and locally
- Potency convention
- 1 mg ≈ 3 IU by conventional labelling
- Presentations
- Lyophilised powder vials with diluent, and prefilled pens or cartridges
- Reference sizes listed
- 10 IU vial; 36 IU pen cartridge; 100 IU kit (10 × 10 IU)
- Storage
- 2–8 °C, protected from light, do not freeze; reconstituted product refrigerated and used within the period stated in the approved labelling
- Intended use
- Reference listing only — prescription medicine, not supplied for non-prescribed use
Questions about HGH (Somatropin) — Prescription Reference
How does growth hormone work at the molecular level?
Somatropin binds one growth hormone receptor at two sites, causing receptor dimerisation and activation of the associated kinase JAK2, which phosphorylates STAT5b. Downstream transcription raises IGF-1, the main mediator of growth effects. Direct receptor effects include stimulation of lipolysis and antagonism of insulin action on glucose uptake.
Why are the sizes given in IU rather than milligrams?
Both units appear on somatropin labelling. Potency was historically expressed in international units, and the conventional equivalence used on modern product is 1 mg to approximately 3 IU. The reference presentations listed here — 10 IU vial, 36 IU cartridge and 100 IU kit — follow the IU convention still common on pens and vials.
Can somatropin be used for muscle building or anti-ageing?
There is no approved indication for athletic performance, bodybuilding or anti-ageing use. Growth hormone is a prohibited substance in sport under the World Anti-Doping Code, and US law restricts distribution to approved indications. This listing describes the molecule and its regulatory status only and offers no such guidance.
Why does it need refrigeration?
Somatropin is a folded 22 kDa protein, and its activity depends on that structure. Warmth, freezing, light and mechanical shear can denature or aggregate it. Product is therefore shipped and stored at 2–8 °C, kept out of the freezer, and used within the in-use period stated in the approved labelling.
Do you provide dosing information?
No. Dosing, monitoring and administration of a prescription biologic are determined by the prescribing clinician using the approved product labelling for the specific brand. This listing is limited to identity, chemistry, mechanism, approved indications, presentations and storage requirements.
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