- ≥99% by HPLC; lot-matched COA
- Lot-matched certificate of analysis
- Ships next business day, tracked
PT-141 (Bremelanotide)
Bremelanotide — cyclic heptapeptide melanocortin receptor agonist
- FormLyophilized white to off-white powder, sealed glass vial
- Mol. weight1025.16 g/mol
- Research areasCentral sexual arousal pathways, appetite and energy balance, melanocortin pharmacology
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide developed as a melanocortin receptor agonist. Structurally it is a close relative of Melanotan II: the C-terminal amide of MT-2 is replaced by a free carboxylic acid, which removes most of the pigmentation-related MC1R activity and shifts the molecule’s preference toward the central MC3R and MC4R subtypes. The lactam bridge between the aspartate and lysine side chains, the N-terminal acetyl group, and the inclusion of norleucine and D-phenylalanine all contribute to its conformational rigidity and resistance to enzymatic degradation.
Specifications
Identity
- CAS number
- 189691-06-3
- Molecular formula
- C50H68N14O10
- Molecular weight
- 1025.16 g/mol
- Amino acid sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (side-chain lactam bridge between Asp and Lys)
- Peptide class
- Cyclic heptapeptide; α-MSH analogue / melanocortin receptor agonist
Supply & purity
- Form
- Lyophilized white to off-white powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Available sizes
- 5 mg, 10 mg, 20 mg
- Solubility
- Readily soluble in bacteriostatic or sterile water; also soluble in dilute acetic acid
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture; stable at room temperature during transit
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Receptor targets
- MC3R and MC4R (principal); weaker MC1R activity than Melanotan II
- Research areas
- Central sexual arousal pathways, appetite and energy balance, melanocortin pharmacology
Questions about PT-141 (Bremelanotide)
What is PT-141 and how does it differ from Melanotan II?
PT-141 (bremelanotide) is the free-acid, deaminated analogue of Melanotan II. That single structural change lowers activity at the pigmentation-linked MC1R while preserving MC3R and MC4R agonism, which is why researchers use PT-141 when they want central melanocortin signalling with less peripheral melanogenic activity.
Is your PT-141 third-party tested, and can I see the COA?
Yes. Every lot is analysed by reverse-phase HPLC and mass spectrometry, and we hold a lot-matched certificate of analysis showing purity of ≥99% along with identity confirmation. Request the COA for the lot you receive and we will provide it; batch numbers on the vial match the document.
What vial sizes are available?
PT-141 is stocked in 5 mg, 10 mg and 20 mg lyophilized vials. Smaller vials suit short pilot experiments or assay development, while the 20 mg size is more economical for extended in vitro series where a single lot keeps the study internally consistent.
How should the lyophilized powder be stored?
Keep sealed vials at −20 °C, away from light and moisture; the lyophilized form tolerates ambient temperature during shipping without meaningful loss. After reconstitution, hold the solution at 2–8 °C, minimise freeze–thaw cycles, and use it within the window your protocol validates.
Does PT-141 cause tanning like Melanotan II?
The pigmentation response reported in Melanotan II literature is driven largely by MC1R activation, and PT-141’s affinity for that receptor is considerably lower. We do not make claims about physiological outcomes — this compound is supplied for laboratory research and any observations belong to the published literature, not to a product promise.
Can I buy PT-141 for personal use?
No. PT-141 is sold as a research chemical for in vitro and laboratory investigation only. It is not a drug, dietary supplement, cosmetic or veterinary product, it has not been supplied for administration to humans or animals, and purchasers confirm they are qualified to handle research materials.
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