- ≥99% by HPLC; lot-matched COA
- Lot-matched certificate of analysis
- Ships next business day, tracked
Humanin
24-residue mitochondrial-derived peptide studied for cytoprotective signaling
- FormLyophilized powder, sealed glass vial
- Mol. weight2687.27 g/mol
- Research areasCytoprotection, apoptosis signaling, neuronal survival models, metabolic and endothelial research
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Humanin is a 24-amino-acid peptide encoded within the mitochondrial 16S rRNA gene (MT-RNR2) and was the first mitochondrial-derived peptide to be characterized. It was discovered in 2001 during a screen of surviving neurons from an occipital lobe sample, which is how it acquired a name that reflects the survival phenotype rather than any chemical property.
Our humanin is produced by solid-phase peptide synthesis, HPLC-purified and lyophilized into sealed vials. Every lot is verified for purity and identity, with a Certificate of Analysis available before purchase. Supplied strictly for laboratory research.
Specifications
Identity
- CAS number
- 330936-69-1
- Molecular formula
- C119H204N34O32S2
- Molecular weight
- 2687.27 g/mol
- Amino acid sequence
- Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
- Peptide class
- Mitochondrial-derived peptide (MDP)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Available sizes
- 5 mg, 10 mg
- Solubility
- Bacteriostatic or sterile water; may require gentle warming
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Gene of origin
- MT-RNR2 (mitochondrial 16S rRNA region)
- Research areas
- Cytoprotection, apoptosis signaling, neuronal survival models, metabolic and endothelial research
Questions about Humanin
What is humanin?
Humanin is a 24-amino-acid peptide encoded in the mitochondrial 16S rRNA gene and was the first mitochondrial-derived peptide identified. It is studied in laboratory models of cell survival, apoptosis signaling and metabolic regulation.
Is this humanin third-party tested?
Yes. Every lot is analyzed by HPLC for purity of ≥99% and by mass spectrometry for identity, and the lot-matched Certificate of Analysis is available on this page before purchase so you can review the data with your own acceptance criteria.
How does humanin differ from MOTS-c?
Both are mitochondrial-derived peptides but they come from different regions of mitochondrial DNA and have different sequences and lengths. Humanin is 24 residues from the 16S rRNA gene; MOTS-c is 16 residues from the 12S region, and their reported signaling profiles differ.
Why is my humanin slow to dissolve?
The sequence contains a leucine-rich hydrophobic core, so it dissolves more slowly than short hydrophilic peptides. Add diluent gently, allow several minutes with swirling, and warm to roughly 25–30 °C if needed rather than shaking the vial.
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