- ≥99% by HPLC; lot-matched COA
- Lot-matched certificate of analysis
- Ships next business day, tracked
MOTS-c
16-amino-acid mitochondrial-derived peptide for metabolic signaling research
- FormLyophilized powder, sealed glass vial
- Mol. weight2174.55 g/mol
- Research areasAMPK signaling, glucose and lipid metabolism, mitochondrial stress response, exercise physiology
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
MOTS-c (mitochondrial open reading frame of the twelve S rRNA type-c) is a 16-amino-acid peptide encoded not in the nuclear genome but within the mitochondrial 12S rRNA gene. It belongs to the small family of mitochondrial-derived peptides (MDPs) alongside humanin and the SHLP series, and it was first described in 2015 as a signal that mitochondria appear to send to the rest of the cell about their metabolic state.
Specifications
Identity
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.55 g/mol
- Amino acid sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Chain length
- 16 amino acids
- Peptide class
- Mitochondrial-derived peptide (MDP)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Available sizes
- 10 mg, 20 mg, 40 mg
- Solubility
- Bacteriostatic or sterile water; aqueous buffers
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Research areas
- AMPK signaling, glucose and lipid metabolism, mitochondrial stress response, exercise physiology
Questions about MOTS-c
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene rather than in nuclear DNA. It is classified as a mitochondrial-derived peptide and is studied in laboratory models of energy metabolism, AMPK signaling and mitochondrial stress responses.
Is this MOTS-c third-party tested?
Yes. Every lot is analyzed by HPLC for purity and by mass spectrometry for identity, and a lot-matched Certificate of Analysis is available on the product page before you order. The COA documents purity, mass confirmation and the analytical methods used.
What sizes are available?
MOTS-c is supplied in 10 mg, 20 mg and 40 mg lyophilized vials. Larger vials reduce the per-milligram cost for laboratories running extended studies, while the 10 mg vial suits pilot experiments and assay development.
How should MOTS-c be stored?
Store the lyophilized powder at −20 °C, protected from light and moisture; at that temperature the material is stable for long periods. Once reconstituted, keep the solution refrigerated at 2–8 °C, aliquot it, and minimize freeze–thaw cycles.
What is MOTS-c dissolved in?
Bacteriostatic water is the most common reconstitution medium in research workflows, and sterile water or standard aqueous buffers are also used depending on the assay. Add diluent slowly along the vial wall and swirl rather than shake.
Is MOTS-c related to humanin?
Both are mitochondrial-derived peptides encoded in mitochondrial DNA, but they are distinct molecules with different sequences, lengths and reported signaling profiles. Humanin is a 24-residue peptide from the 16S rRNA region; MOTS-c is 16 residues from the 12S region.
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