- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
MOTS-c Oral Capsules
Oral MOTS-c research capsules, 5 mg per capsule, 30-count bottle
- FormOral capsule in a sealed bottle with tamper-evident closure
- Mol. weight2174.55 g/mol
- Research areasAMPK signalling, one-carbon and folate metabolism, glucose and lipid handling, oral peptide stability and bioavailability, exercise physiology
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene rather than in nuclear DNA — one of a small group of peptides, alongside humanin and the SHLPs, that arise from the mitochondrial genome. This listing supplies it in a fixed-content oral capsule at 5 mg per unit, 30 capsules per sealed bottle, formulated from ≥99% HPLC-purity peptide with a lot-matched certificate of analysis.
The peptide itself is identical to the material in our lyophilized vials: sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, formula C101H152N28O22S2, about 2174.55 g/mol. Published work associates it with AMPK activation, the folate–methionine one-carbon cycle, glucose and lipid handling, and translocation to the nucleus under metabolic stress where it has been reported to influence adaptive gene expression.
Specifications
Identity
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.55 g/mol
- Amino acid sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Chain length
- 16 amino acids
Supply & purity
- Form
- Oral capsule in a sealed bottle with tamper-evident closure
Additional detail
- Peptide per capsule
- 5 mg MOTS-c
- Available size
- 30 capsules (150 mg total peptide per bottle)
- Peptide purity
- ≥99% by HPLC; lot-matched COA available
- Active peptide
- MOTS-c, mitochondrial-derived peptide (MDP)
- Genomic origin
- Short open reading frame within the mitochondrial 12S rRNA gene
- Research areas
- AMPK signalling, one-carbon and folate metabolism, glucose and lipid handling, oral peptide stability and bioavailability, exercise physiology
- Storage
- Cool, dry and dark; refrigeration extends shelf stability
- Preparation required
- None — fixed unit content, no reconstitution step
Questions about MOTS-c Oral Capsules
How much MOTS-c is in each capsule?
Each capsule contains 5 mg of MOTS-c, and each sealed bottle holds 30 capsules, for 150 mg of peptide per bottle. The unit content is fixed at manufacture, so no weighing or reconstitution is needed for studies designed around whole units.
Is MOTS-c orally bioavailable?
Peptides of this size are generally degraded by gastric acid and intestinal proteases and absorbed poorly, so systemic bioavailability from an oral route should be assumed to be low unless a study demonstrates otherwise. This format is intended for stability, formulation and gut-local research rather than as an equivalent to parenteral delivery.
Do you provide a certificate of analysis?
Yes. A lot-matched COA is available covering the peptide used in the capsule fill, including HPLC purity of ≥99% and mass-spectrometric identity confirmation. Quote the lot number printed on the bottle label when requesting the document.
What is a mitochondrial-derived peptide?
It is a peptide encoded by a short open reading frame inside the mitochondrial genome rather than nuclear DNA. MOTS-c comes from the 12S rRNA gene; humanin and the SHLPs are the other well-known members. They are studied as signals from mitochondria to the rest of the cell.
Can these capsules be taken as a supplement?
No. They are a research article supplied for laboratory investigation only, not a dietary supplement or medicine. They are not manufactured or labelled for human consumption, carry no directions for use, and must not be administered to humans or animals.
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