- ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
SS-31 (Elamipretide) Peptide
Elamipretide tetrapeptide studied for cardiolipin binding in mitochondria
- FormLyophilized powder, sealed glass vial
- Mol. weight639.80 g/mol
- Research areasCardiolipin interaction, cristae structure, reactive oxygen species, ischemia–reperfusion models
Overview
SS-31, also known as elamipretide and historically as MTP-131 or Bendavia, is a synthetic tetrapeptide built on the Szeto–Schiller aromatic-cationic scaffold. Its sequence, D-Arg-Dmt-Lys-Phe-NH2, alternates basic and aromatic residues and incorporates a D-arginine and the unnatural amino acid 2',6'-dimethyl-L-tyrosine (Dmt), a design that gives the molecule unusual resistance to peptidase cleavage for its size.
Supplied as a lyophilized powder in a sealed vial, our SS-31 is manufactured by solid-phase synthesis and purified by preparative HPLC. Every lot carries a Certificate of Analysis with HPLC purity and mass-spectrometric identity data.
Specifications
Identity
- CAS number
- 736992-21-5
- Molecular formula
- C32H49N9O5
- Molecular weight
- 639.80 g/mol
- Amino acid sequence
- D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2',6'-dimethyl-L-tyrosine)
- Peptide class
- Szeto–Schiller aromatic-cationic mitochondria-targeting peptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Available sizes
- 10 mg, 30 mg, 50 mg
- Solubility
- Freely soluble in water and bacteriostatic water
Handling & storage
- Storage (lyophilized)
- −20 °C, protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, used within the study window
Additional detail
- Also known as
- Elamipretide, MTP-131, Bendavia
- Research areas
- Cardiolipin interaction, cristae structure, reactive oxygen species, ischemia–reperfusion models
Working out the concentration
SS-31 (Elamipretide) ships as a lyophilized powder, so nothing on this page can state a concentration: the figure you work with is the one you create when you add diluent. Put the vial mass and the volume you intend to use into the peptide reconstitution calculator and it returns mg/mL, mcg/mL and the mass sitting at each mark on a U-100 syringe.
If the protocol asks for a molar concentration, the molar concentration calculator converts between 639.80 g/mol, the mass you weigh out and the volume you dissolve it in.
Certificate of analysis
Every lot of SS-31 (Elamipretide) is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about SS-31 (Elamipretide)
What is SS-31?
SS-31 is a synthetic four-residue aromatic-cationic peptide, also called elamipretide, designed by the Szeto–Schiller group. It is studied in laboratory settings for its reported affinity for cardiolipin in the inner mitochondrial membrane and its use as a tool compound in bioenergetics research.
How is purity verified?
Each lot is tested by reverse-phase HPLC for purity of ≥99% and by mass spectrometry for identity against the expected molecular weight of 639.80 g/mol. The lot-matched Certificate of Analysis is available before purchase and documents both results.
What sizes can I order?
SS-31 is available in 10 mg, 30 mg and 50 mg lyophilized vials. Because the molecule is small, a given milligram amount contains substantially more molar material than an equivalent mass of a larger peptide such as MOTS-c.
How should it be stored?
Keep the lyophilized vial at −20 °C, protected from light and moisture. After reconstitution, store at 2–8 °C, keep the container shielded from light, and aliquot so that the working solution is not repeatedly frozen and thawed.
Related
